Results 181 to 190 of about 28,240 (212)
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The spironolactone renaissance
Expert Opinion on Investigational Drugs, 2001Until recently, spironolactone was considered only as an antagonist at the aldosterone receptors of the epithelial cells of the kidney and was used clinically in the treatment of hyperaldosteronism and, occasionally, as a K(+)-sparing diuretic. The spironolactone renaissance started with the experimental finding that spironolactone reversed aldosterone-
Doggrell, Sheila A., Brown, Lindsay
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Spironolactone for hypertension
Cochrane Database of Systematic Reviews, 2010Spironolactone is an aldosterone antagonist, considered fourth line therapy for hypertension in patients already treated with multiple medications.Primary: to determine the effect of spironolactone on patient mortality, morbidity, and to quantify the magnitude of blood pressure lowering effect of spironolactone monotherapy.Secondary: to determine the ...
Josh Batterink +3 more
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Neonatal Network, 1999
DIURETICS ARE COMMONLY USED IN the neonatal intensive care unit (NICU) to remove excess extracellular fluid secondary to various diseases, such as chronic lung disease (CLD) and congestive heart failure (CHF). Diuretics are among the most used of all medications across age groups.
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DIURETICS ARE COMMONLY USED IN the neonatal intensive care unit (NICU) to remove excess extracellular fluid secondary to various diseases, such as chronic lung disease (CLD) and congestive heart failure (CHF). Diuretics are among the most used of all medications across age groups.
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Spironolactone and Endocrine Dysfunction
Annals of Internal Medicine, 1976Therapy with spironolactone is often associated with estrogenlike side-effects, including impotence and gynecomastia in men and menstrual irregularity in women. Several possible mechanisms by which spironolactone could cause these side-effects have been identified.
Julio C. Pita +4 more
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ALDOSTERONISM AND SPIRONOLACTONE
Annals of Internal Medicine, 1969Excerpt To the Editor:I was very interested in the article entitled "Aldosteronism in Hypertension: The Response to Spironolactone" by Spark and Melby (Ann. Intern. Med. 69: 685, 1968).
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Spironolactone‐induced hepatitis
Australasian Journal of Dermatology, 2001SUMMARYThere is widespread use of spironolactone in medical practice and the indications for its use well established and side effect profile well known. Herein, we present a case of drug‐induced hepatitis occurring in a 50‐year‐old woman using spironolactone for the treatment of androgenetic alopecia. Six weeks after commencement of spironolactone the
Keng-Ee Thai, Rodney Sinclair
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Spironolactone-Induced Agranulocytosis
Drug Intelligence & Clinical Pharmacy, 1987Agranulocytosis associated with spironolactone administration is described in a 57-year-old man. Four days after initiation of spironolactone, leukocyte counts decreased from 8.2 to 2.3 × 109/L with 6% neutrophils. Spironolactone, domperidone, and prochlorperazine were discontinued.
Kabirudeen T. Jivraj +5 more
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Spironolactone: A Re-Examination
DICP, 1990A review of the aldosterone antagonist spironolactone is presented. It is effective both as monotherapy and in combination with other hypotensive agents in the control of both essential and hyperaldosterone-induced hypertension. It is useful as a diuretic in conditions such as cirrhosis and congestive heart failure, and is most commonly employed ...
Hilary A. Skluth, John G. Gums
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Spironolactone. II. Bioavailability
Clinical Pharmacology & Therapeutics, 1976The bioavailability of commercial 25‐mg spironolactone tablets and a new tablet preparation containing 100 mg of the drug has been determined in 12 healthy male subjects. After a 200‐mg oral dose of the drug given in a solution of polyethylene glycol‐400, the peak plasma level of the dethioacetylated metabolite canrenone was 633 ± 154 ng Iml (mean ± SD)
B. J. Baltes +4 more
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Hydrochlorothiazide and spironolactone in hypertension
Clinical Pharmacology & Therapeutics, 1979A double‐blind study of hydrochlorothiazide and spironolactone, alone and in combination, was conducted in 49 patients with mild‐to‐moderate essential hypertension after a 4‐wk placebo washout period. In the whole group mean arterial blood pressure fell to levels of ≤107 mm Hg or declined by more than 15 mm Hg in 78% of the patients after twelve weeks ...
Myron H. Weinberger, G Schrijver
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