Results 151 to 160 of about 1,381 (201)

Strategies for the enantioselective synthesis of spirooxindoles

Organic & Biomolecular Chemistry, 2012
Oxindoles and spirooxindoles are important synthetic targets that are often considered to be prevalidated with respect to their biological activity and applications for pharmaceutical lead discovery. This review features efficient strategies for the enantioselective synthesis of spirocyclic oxindoles, focusing on reports in 2010 and 2011.
Nicolas R, Ball-Jones, Joseph J, Badillo, Annaliese K, Franz   +2 more
openaire   +2 more sources

Spirooxindoles as Potential Pharmacophores

Mini-Reviews in Medicinal Chemistry, 2017
The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
Siva S, Panda, Rachel A, Jones, Praveen, Bachawala, Prabhu P, Mohapatra   +3 more
openaire   +3 more sources

Efficient synthesis of spirooxindole-pyrrolizidines and dispirooxindole-piperazines

Synthetic Communications, 2018
A simple and efficient approach for the construction of spirooxindole-pyrrolizidines and dispirooxindole-piperazines by cycloaddition reaction of azomethine ylide generated by isatin and proline has been demonstrated successfully.
Keshri Nath Tiwari, Suyash Pant
exaly   +2 more sources

Diastereoselective Synthesis and Structure of Spirooxindole Derivatives

HETEROCYCLES, 2003
Spiroindolinonisoxazolines (4 and 5h) are prepared from (E)- 1 or (Z)-3-arylidene-2-oxindoles (2) by nitrile oxide cycloaddition reactions. Only one regioisomer is detected in all cases, and the observed complete diastereoselection is established by unambigous structural assignments.
RISITANO, Francesco, GRASSI, Giovanni, FOTI, Francesco, BRUNO, Giuseppe, ROTONDO, Archimede   +4 more
openaire   +2 more sources

Spirooxindoles: Promising scaffolds for anticancer agents

European Journal of Medicinal Chemistry, 2015
The search for novel anticancer agents with more selectivity and lower toxicity continues to be an area of intensive investigation. The unique structural features of spirooxindoles together with diverse biological activities have made them privileged structures in new drug discovery.
Bin, Yu, De-Quan, Yu, Hong-Min, Liu
openaire   +2 more sources

Collective chemical syntheses of spirooxindole alkaloids

Spirooxindole alkaloids and their derivatives exhibit excellent biological activities in different aspects bearing a potential of pharmaceutical application. Many synthetic chemists were attracted to synthesize this type of compounds efficiently.
Cheung, Yuen Tsz
openaire   +2 more sources

Molecular diversity of spirooxindoles. Synthesis and biological activity

Molecular Diversity, 2015
Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Tetyana L, Pavlovska, Ruslan Gr, Redkin, Victoria V, Lipson, Dmytro V, Atamanuk   +3 more
openaire   +2 more sources

Catalytic asymmetric synthesis of spirooxindoles: recent developments

Chemical Communications, 2018
The past four years have witnessed significant developments in the field of the catalytic asymmetric synthesis of spirooxindoles, and this feature article outlines the recent progress in this area, including the contributions of our group. This article is divided into sections according to the size and type of the generated spiro-ring fused at the C3 ...
Guang-Jian Mei, Feng Shi
openaire   +2 more sources

Titanium-Catalyzed Stereoselective Synthesis of Spirooxindole Oxazolines

Organic Letters, 2010
A regio- and stereoselective cyclization between isatins and 5-methoxyoxazoles has been developed using catalytic titanium(IV) chloride (10 or 20 mol %) to afford spiro[3,3'-oxindoleoxazolines] in excellent yield (up to 99%) and diastereoselectivity (dr >99:1). Substitution at the 4-position of the oxazole controls nucleophilic attack to provide either
Joseph J, Badillo, Gary E, Arevalo, James C, Fettinger, Annaliese K, Franz   +3 more
openaire   +2 more sources

Superacid-Promoted synthesis of spirooxindoles

Tetrahedron Letters, 2023
Jacob C. Hood, Hien Vuong, Douglas A. Klumpp   +2 more
openaire   +1 more source