Results 61 to 70 of about 612,842 (306)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

THE SPLEEN [PDF]

British Journal of Haematology, 2002
  +7 more sources

Dose-dependent tuning of HSP70–Beclin-1 by kaempferol governs autophagy and chemosensitivity

Frontiers in Oncology
IntroductionAutophagy can either support cell survival or promote cell death in response to therapeutic stress, yet the molecular switch that determines this directionality remains poorly defined.MethodsUsing kaempferol as a proof‑of‑concept flavonoid ...
Suqin Hu, Yanan Guo, Mingyan Li, Fangli Jin, Lei Luo, Zhihuan Yan, Jing Wang, Bao Liu, Qinsheng Zhang, Wenzhao Luo   +9 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Development and validation of a 24-h predictive model for hypertriglyceridemic moderately severe acute pancreatitis: a single-center retrospective study

Frontiers in Medicine
ObjectiveTo develop and validate a risk prediction model for identifying patients with hypertriglyceridemia-induced acute pancreatitis who are at risk of progressing to moderately severe acute pancreatitis (MSAP) within 24 h after admission, thereby ...
Songlong Yang, Songlong Yang, Chaoqun Li, Chaoqun Li, Kaiping Zeng, Kaiping Zeng, Minguang Zhang, Minguang Zhang, Wenrong Wang, Wenrong Wang   +9 more
doaj   +1 more source

Laparoscopic splenectomy of a wandering spleen with coincidental enormous splenomegaly

, 2012
Ectopy of the spleen also referred to as wandering spleen is a rare condition and preferentially treated by laparoscopic splenopexy. However, in complicated cases with torsion and consecutive infarction of the spleen splenectomy is required.
Juchems, Markus, Henne-Bruns, D, Juchems, M, Henne-Bruns, Doris, Scheele, J, Lemke, J, Brockschmidt, C, Lemke, Johannes, Brockschmidt, Claas, Scheele, Jan   +9 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

T cell-specific suppressor factor(s) with regulatory influence on interleukin 2 production and function [PDF]

, 1982
In this study we report that alloantigen-activated spleen cells produce both amplifying and suppressive factors under the same conditions. Both types of soluble mediators--as detected in different assay systems-- were present in the supernatants of in ...
Michael Kramer, Ulrich Koszinowski, Koszinowski, Ulrich H., Kramer, M.   +3 more
core   +1 more source

Noradrenergic and Cholinergic Reinnervation of Islet Grafts in Diabetic Rats [PDF]

, 1996
Grafted islets become denervated due to the islet transplantation procedure. The aim of the present study was 1) to examine whether islet grafts in the liver, the spleen, and under the kidney capsule in rats become reinnervated following the ...
Oestreicher, AB, Strubbe, JH, van der Zee, E A, Suylichem, Paul T.R. van,, Oestreicher, A B, Asperen, Roelie M. van,, Strubbe, Jan H.,, VanAsperen, RM, Steffens, Anton B.,, Houwing, H, van Suylichem, P T R, Eddy A. Van Der Zee, Steffens, AB, Zee, Eddy A. van der,, Harmina Houwing, VanderZee, EA, Strubbe, J H, Houwing, Harmina,, van Asperen, R M, Oestreicher, A. Beate,, Jan H. Strubbe, Van Suylichem, PTR, Paul T.R. Van Suylichem, Steffens, A B, Roelie M. Van Asperen, Asperen, Roelie M. van, A. Beate Oestreicher, Anton B. Steffens   +27 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source