Results 41 to 50 of about 490,454 (267)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Nursing strategies after pancreaticoduodenectomy: continuity of care combined with immunomodulatory nutrition

Frontiers in Surgery
BackgroundPancreaticoduodenectomy (PD) is a highly invasive procedure with a long operation time, resulting in a high incidence of postoperative complications. The quality of patient care remains a key factor in improving prognosis.
Xiaodong Feng, Wei Li, Yufu Tang, Lei Han, Ting Bi, Wei Zhang, Yuqing Miao   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Curzerene suppresses hepatocellular carcinoma progression through the PI3K/AKT/MTOR pathway

Revista de Investigación Clínica
Background: Hepatocellular carcinoma (HCC) is one of the most aggressive cancers worldwide. Curzerene is a sesquiterpene and component of Curcuma rhizomes and has anti-tumor and anti-inflammatory properties.
Yihui Luo, Zhenchang Wang, Jun’e Jiang, Shanshan Wu, Yang Zhai   +4 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

The spleen [PDF]

British Journal of Haematology, 2002
  +7 more sources

Clinical analysis on comparison of outcomes between partial splenic artery embolization and splenectomy for management of grade II–III splenic injury in blunt trauma

European Journal of Medical Research
Background The spleen is also the largest lymphoid organ and has important immune and haematopoietic functions. Traumatic splenic rupture often results in haemorrhagic shock and is life-threatening.
Xiaolong Xu, Meng Lv, Cheng Wang, Jianfeng Mei   +3 more
doaj   +1 more source

TBA-MLR score: a metabolic-immune prognostic biomarker for postoperative hepatocellular carcinoma

Frontiers in Immunology
ObjectiveTo develop and validate a novel prognostic score combining serum total bile acid (TBA) and monocyte-to-lymphocyte ratio (MLR) for improved risk stratification in hepatocellular carcinoma (HCC) patients after radical hepatectomy.MethodsIn 508 HCC
Yuanquan Zhao, Wei Huang, Xiwen Deng, Pengyang Li, Siyang Yao, Yongyu Yang, Xiaofeng Dong   +6 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Dose-dependent tuning of HSP70–Beclin-1 by kaempferol governs autophagy and chemosensitivity

Frontiers in Oncology
IntroductionAutophagy can either support cell survival or promote cell death in response to therapeutic stress, yet the molecular switch that determines this directionality remains poorly defined.MethodsUsing kaempferol as a proof‑of‑concept flavonoid ...
Suqin Hu, Yanan Guo, Mingyan Li, Fangli Jin, Lei Luo, Zhihuan Yan, Jing Wang, Bao Liu, Qinsheng Zhang, Wenzhao Luo   +9 more
doaj   +1 more source