Results 51 to 60 of about 808,301 (296)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Prognostic impact of albumin-bilirubin score in predicting the long-term survival of distal cholangiocarcinoma after radical surgery

World Journal of Surgical Oncology
Background The Albumin-Bilirubin Score (ALBI) serves as an indicator of nutritional status and is a widely recognized prognostic biomarker in cancer patients.
Jin-Can Huang, You-Wei Ma, Han-Xuan Wang, Ren Lang, Tao Jiang   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Effect and satisfaction analysis of perioperative nursing in secondary hyperparathyroidism

Journal of the Pakistan Medical Association
Objective: To assess the effect and satisfaction of perioperative nursing in secondary hyperparathyroidism patients. Method: The study was conducted at the General Hospital of Northern Theatre Command, Shenyang, China, from January 2021 to December 2022,
Xiaodong Feng, Ting Bi, Wei Li, Yang Tong,  Yufu Tang, Sijia Bai, Guangming Cheng, Jie Qin, Wei Zhang   +8 more
doaj   +1 more source

Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda. [PDF]

, 2009
OBJECTIVE: To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda. METHODS: Retrospective analysis of VL patients' clinical data collected for project monitoring by Médecins Sans Frontières in ...
Bern, Bryceson, Chappuis, Collin, Croft, Delgado, Desjeux, Guerin, Jamjoom, Lyons, Moore, Mueller, Mueller, Olliaro, Ritmeijer, Ritmeijer, Seaman, Sundar, Thakur, Veeken, WHO   +20 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The efficacy and safety of thymosin alpha-1 combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a retrospective study

Scientific Reports
To validate the efficacy and safety of thymosin α-1 combined with lenvatinib plus sintilimab in the treatment of unresectable hepatocellular carcinoma.
Siyang Yao, Qiangsong Huang, Yan Zou, Tianqi Liu, Yongyu Yang, Tao Huang, Yuanquan Zhao, Xiaofeng Dong   +7 more
doaj   +1 more source

Nursing strategies after pancreaticoduodenectomy: continuity of care combined with immunomodulatory nutrition

Frontiers in Surgery
BackgroundPancreaticoduodenectomy (PD) is a highly invasive procedure with a long operation time, resulting in a high incidence of postoperative complications. The quality of patient care remains a key factor in improving prognosis.
Xiaodong Feng, Wei Li, Yufu Tang, Lei Han, Ting Bi, Wei Zhang, Yuqing Miao   +6 more
doaj   +1 more source

Gut Microbial Dysbiosis and Changes in Fecal Metabolic Phenotype in Precancerous Lesions of Gastric Cancer Induced With N-Methyl-N′-Nitro-N-Nitrosoguanidine, Sodium Salicylate, Ranitidine, and Irregular Diet

Frontiers in Physiology, 2021
Background and Aims: Precancerous lesions of gastric cancer (PLGC) are the most important pathological phase with increased risk of gastric cancer (GC) and encompass the key stage in which the occurrence of GC can be prevented.
Fuhao Chu, Fuhao Chu, Fuhao Chu, Yicong Li, Xiangmei Meng, Xiangmei Meng, Yuan Li, Yuan Li, Tao Li, Tao Li, Mengyin Zhai, Mengyin Zhai, Haocheng Zheng, Haocheng Zheng, Tianxi Xin, Tianxi Xin, Zeqi Su, Zeqi Su, Jie Lin, Jie Lin, Ping Zhang, Xia Ding, Xia Ding   +22 more
doaj   +1 more source