Results 121 to 130 of about 20,678 (288)

Immune strategies using single-component LipL32 and multi-component recombinant LipL32-41-OmpL1 vaccines against leptospira

Brazilian Journal of Medical and Biological Research, 2009
Genes encoding lipoproteins LipL32, LipL41 and the outer-membrane protein OmpL1 of leptospira were recombined and cloned into a pVAX1 plasmid. BALB/c mice were immunized with LipL32 and recombined LipL32-41-OmpL1 using DNA-DNA, DNA-protein and protein ...
C.Y. Feng, Q.T. Li, X.Y. Zhang, K. Dong, B.Y. Hu, X.K. Guo   +5 more
doaj  

Ushikulide C, a New Immunosuppressant from sp. IUK-102

Natural Product Communications, 2013
Ushikulide C ( 1 ), a new immunosuppressant, was isolated from the culture broth of Streptomyces sp. IUK-102. The structure of 1 is a new 22-membered macrolide that is related to ushikulides A ( 2 ) and B ( 3 ).
Kosaku Takahashi, Eri Fukushi, Jun Kawabata, Hideyuki Matsuura, Kazuhiko Kurosawa   +4 more
doaj   +1 more source

Expression of CBR in splenocyte populations related to the innate immune response.

, 2019
Analysis of the expression of CB1 and CB2 CBR in splenocyte populations from the innate immune response (NK’s and macrophages) among experimental groups: SED (shaded bar), TC (white bar) and EXE (Solid bar); data from 4 independent experiments are ...
Karen Elizabeth Nava-Castro (6940340), René Drucker-Colín (2950836), Salvador Valencia-Sánchez (7878773), Margarita Isabel Palacios-Arreola (7878776), Jorge Morales-Montor (390508), Oscar Prospéro-García (7878779)   +5 more
core   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Expression of cardiac specific PI3K p110α did not significantly alter splenocyte apoptosis in response to CLP sepsis.

, 2013
Splenocytes were harvested 16 h after induction of CLP sepsis.
Kevin F. Breuel (303285), Tammy R. Ozment (303282), John Kalbfleisch (303291), Tuanzhu Ha (303283), Fang Hua (261296), Chen Lu (135200), Ming Gao (115719), Chuanfu Li (303297), Race L. Kao (306730), Tiffany Ford (306729), Krishna Singh (306728), David L. Williams (85105)   +11 more
core   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice

Acta Pharmaceutica, 2017
Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy.
Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser   +4 more
doaj   +1 more source

Result of splenocyte proliferation assay of preparation of Pteridium aquilinum

, 2021
Bracken (Pteridium aquilinum, L. Kuhn), which is used widely in the Eastern and Western medicine and food, has attracted researchers interest. It is related with norsesquiterpene glucoside ptaquiloside, which is carcinogen, contained in the bracken.
Tseesuren, Byambajav, Punsantsogvoo, Otgonsugar, Tumbaa, Undarmaa, Tserendorj, Undrakhbayar, Khishig, Selenge, Ulziibaatar, Otgonjargal   +5 more
core  

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Study the Effect of Echinacea Purpurea Extract on Cellular Delayed Type Hypersensitivity and Splenocyte Proliferation in BALB/c Mice [PDF]

Cell Journal, 2008
Objective: Purple cone flower plant (Echinacea purpurea) is one of the mostimportant Herbal products in many countries. Up to now a lot of experimentsdemonstrated the controversial effects of this herb on immune system .
Z.M. Hassan, H. Soleimanjahi, A. Ghaemi, S. Soudi, S.M. Hashemi   +4 more
doaj