Results 121 to 130 of about 17,686 (257)

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ+CD4−CD8− Double Negative T Cells in lpr Lupus Mice

Immunology, EarlyView.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai, Zhuang Wang, Bettina Heid, Christopher M. Reilly, S. Ansar Ahmed   +4 more
wiley   +1 more source

Heat-killed <i>Lacticaseibacillus casei</i> OS1423 retains immunoprotective functionality across ingredient and adlay tea formulations. [PDF]

Curr Res Food Sci
Park HJ, Kim YT, Kwon JG, Kim HJ, Lee JH, Kang CG, Lee JH.   +6 more
europepmc   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, EarlyView.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Immune-Enhancing Effects of IBP35, a Combination of <i>Lactiplantibacillus plantarum</i> and <i>Ligilactobacillus salivarius</i>, in Macrophages and Cyclophosphamide-Induced Immunosuppressed Mice. [PDF]

Food Sci Nutr
Lee HB, Lee J, Jeong K, Jung YH, Moon JS.   +4 more
europepmc   +1 more source

BCL‐2 and MCL1 co‐inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A‐rearranged acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Mawar Karsa, Ayu Karsa, Dayna Spurling, Lin Xiao, Emma Ronca, Angelika Bongers, Weiman Gao, Andrew J. Gifford, Ali El‐Ayoubi, Laurence C. Cheung, Rishi S. Kotecha, Richard B. Lock, Charis E. Teh, Guillaume Lessene, Murray D. Norris, Andrew Wei, Michelle Haber, Michelle J. Henderson, Donia M. Moujalled, Klaartje Somers   +19 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Chimeric autoantibody receptor T cells for targeted depletion of myeloperoxidase-specific anti-neutrophil cytoplasmic antibody-producing B cells. [PDF]

Front Immunol
Sosnoski HM, Aguilar W, Brookens SK, Degaramo DA, Keane JT, Lewis HS, Gullipalli D, Song W, Posey AD.   +8 more
europepmc   +1 more source

Polatuzumab Vedotin Enhances Intratumoral T‐Cell Infiltration and Demonstrates Combinatorial Efficacy With Anti‐CD20/CD3 Bispecific Antibody in a Syngeneic B‐Cell Malignancy Mouse Model

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Introduction Polatuzumab vedotin (Pola) is an anti‐CD79b antibody‐drug conjugate. Clinical evidence supports the combination efficacy of Pola with mosunetuzumab or glofitamab, both anti‐CD20/CD3 bispecific antibodies (anti‐CD20/CD3 BsAbs). However, the influence of Pola on the tumor microenvironment and its impact on the efficacy of anti‐CD20 ...
Mayu Tomita, Sei Shu, Natsumi Kawasaki, Satoko Takagi, Shigeki Yoshiura, Yoriko Yamashita‐Kashima   +5 more
wiley   +1 more source

Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota. [PDF]

Eur J Immunol
Philip CS, Filippov I, Haljasorg U, Peterson P.   +3 more
europepmc   +1 more source

Investigation of the Effects of Perfluorooctane Sulfonic Acid (PFOS) and Perfluorooctanoic Acid (PFOA) Exposure on Interleukin‐17 Signalling and Poly(I:C)‐Induced Lung Inflammation in BALB/c Mice

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT The aim of this study was to investigate the effects of co‐exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on the IL‐17‐related immune responses and the Poly(I:C)‐induced lung inflammation. A total of 66 adult male BALB/c mice were divided into 11 groups, including controls, dose groups receiving PFOS+PFOA (1,
Eda Nur İnkaya, Seçil Karahisar Turan, Nurhayat Barlas   +2 more
wiley   +1 more source