Results 161 to 170 of about 17,686 (257)

Erianin Targets PINK1/Parkin‐Mediated Mitophagy and Apoptosis to Ameliorate Atopic Dermatitis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Erianin activates PINK1/Parkin‐mediated mitophagy, reduces ROS accumulation, inhibits mitochondrial apoptosis, and alleviates skin inflammation in atopic dermatitis. ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin lesions. Mitochondrial dysregulation is associated with various pathologic conditions, including inflammation in the skin ...
Kexin Xu, Lianhua Zhu, Shan Jin, Wenyu Jin, Zhehu Jin, Guanghai Yan, Liangchang Li   +6 more
wiley   +1 more source

A Trypanothione Synthetase-Based Subunit Vaccine Induces Protective Th1 Immunity against Visceral Leishmaniasis in Mice. [PDF]

ACS Pharmacol Transl Sci
Khan E, Chatterjee A, Kumar S, Madhukar P, Singh VK, Singh SS, Sundar S, Kumar R, Dubey VK.   +8 more
europepmc   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice. [PDF]

J Gen Virol
Dvorak M, Arbon D, Salat J, Fortova A, Pajuelo Reguera D, Frckova T, Holoubek J, Balounova J, Prochazka J, Sedlacek R, Ruzek D.   +10 more
europepmc   +1 more source

Eliminating PD‐L1 on Dendritic Cell Extracellular Vesicles for Immunotherapy Potentiates Immune‐Mediated Tumour Rejection in Mice

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Extracellular vesicles (EVs) for immune therapy of cancer have both direct and indirect effects on immune cells. When taken up, the loaded antigen is presented by the host's dendritic cells (indirect). In this case, EV surface molecules like MHC‐peptide complexes on EVs are of minor importance. Here we show that removal of PD‐L1 from the surface of EVs
Loes Teeuwen, Loïc Steiner, Chantal Reinhardt, Annemarijn Offens, Jesse E. Kuipers, Daniel Martínez‐Martínez, Jules Mazouin, Benedict J. Chambers, Gözde Güçlüler Akpinar, Susanne Gabrielsson   +9 more
wiley   +1 more source

Upregulation of innate and adaptive immune mechanisms facilitating prevention of gastric <i>Helicobacter pylori</i> infection in guinea pigs by <i>per os</i> administration of chitosan microparticles loaded with <i>Mycobacterium bovis</i> BCG. [PDF]

Front Immunol
Gonciarz W, Brzeziński M, Wosiak A, Jeleń A, Balcerczak E, Chmiela M.   +5 more
europepmc   +1 more source

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Protective Immunity Induced by DNA Vaccines Encoding TgGRA47 and TgGRA72 Against <i>Toxoplasma gondii</i> Infection in BALB/c Mice. [PDF]

Transbound Emerg Dis
Zhou Z, Mu J, Sun J, Chen J, Zhou C.
europepmc   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

A chimeric trivalent Echovirus vaccine designed by loop substitution elicits cross-neutralizing immunity against serotypes 11, 18, and 30. [PDF]

J Virol
Jiang S, Cui J, Sun T, Li J, Li H, Chen T, Wu J, Zheng Z, Xia J, Wu C, Wu J.   +10 more
europepmc   +1 more source