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The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ + CD4 − CD8 − Double Negative T Cells in lpr Lupus Mice

Immunology, Volume 179, Issue 2, Page 224-235, October 2026.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai +4 more
wiley +1 more source

Compositional alterations in immune cells from obese mice impair anti-tumor cytotoxicity in pancreatic ductal adenocarcinoma. [PDF]

Food Nutr Res
Jeong I, Kim OK.
europepmc +1 more source

From Parasite to Therapy: Immunomodulatory Effects of a Trichuris trichiura Derived Recombinant Protein in Allergic Airway Disease

Clinical &Experimental Allergy, EarlyView.
Jessica Cristiane da Conceição de Andrade +14 more
wiley +1 more source

d‐Sorbose Promotes Regulatory T‐Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
d‐Sorbose promotes Foxp3+ Treg differentiation ex vivo and exerts potent anti‐inflammatory effects in vivo, ameliorating allergic airway inflammation and preventing autoimmune diabetes without compromising T cell viability or inducing toxicity.
Fumiaki Sato +12 more
wiley +1 more source

Ginsenoside Rh2 Enhances CD8<sup>+</sup> T Cell-Mediated Anticancer Immunity in Hepatocellular Carcinoma. [PDF]

Nutrients
Park J, Jeong I, Han A, Kim OK.
europepmc +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, Volume 15, Issue 34, 11 September 2026.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley +1 more source

The Study of Effects of Monophenolic Antioxidants, Sodium Anphen and Potassium Phenosan, on Cell Apoptosis by Fluorescence and Confocal Microscopy. [PDF]

Int J Mol Sci
Mil EM +5 more
europepmc +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, Volume 13, Issue 49, 3 September 2026.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu +7 more
wiley +1 more source

Immunomodulatory Effects of Bifidobacterium bifidum BGN4 in Cyclophosphamide-induced Immunosuppressed Mice via Activation of NK Cells and Macrophages. [PDF]

Probiotics Antimicrob Proteins
Kim S +11 more
europepmc +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, Volume 13, Issue 52, 18 September 2026.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source

medicine
apoptosis