Results 171 to 180 of about 17,686 (257)

Age‐Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age

Aging Cell, Volume 25, Issue 7, July 2026.
Decidual macrophages (DM) in advanced maternal age (AMA) exhibit FOXO3 deficiency‐driven senescence, further accelerated by elevated uterine IL‐6. This manifests as pro‐inflammatory polarization, increased senescence markers, reduced phagocytosis, and impaired trophoblast function.
Yujing Zhang, Yiming Zhang, Guangshun Gong, Zhijing Li, Wenjing Xiong, Xuhui Fang, Ning Lu, Di Wang, Yihui Li, Aihua Liao   +9 more
wiley   +1 more source

Tn-Glycoconjugates engage MGL2 to potentiate TLR9-mediated dendritic cell maturation and Th1-skewed immune responses. [PDF]

Innate Immun
Chiale C, Bay S, Ganneau C, Freire T.
europepmc   +1 more source

GW9508‐Induced Activation of GPR40 in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

Aging Cell, Volume 25, Issue 7, July 2026.
GW9508 activates GPR40 to trigger Ca2+ influx and AMPKα signaling, repressing ERK1/2‐MAPK cascade. This pathway alleviates thymic epithelial cell senescence and restores T cell production to counteract thymus aging. ABSTRACT Age‐associated thymic involution leads to a reduction of T‐cell production, which constitutes a primary factor in ...
Qingqing Li, Ping Zhu, Lihong Cui, Fenghua Luo, Yongqin Zhou, Yuanyuan Hu, Chunyan Luo, Shanshan Han, Xie Ding, Maoxi Yao, Honggang Yuan, Yinhong Song   +11 more
wiley   +1 more source

Sex differences in donor T cell targeting of host splenocyte subpopulations in acute and chronic murine graft-vs-host disease: results from a novel induction and assessment protocol with implications for lupus-like autoimmunity. [PDF]

Immunohorizons
Soloviova K, Via CS.
europepmc   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, Volume 81, Issue 7, Page 2343-2356, July 2026.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, Volume 209, Issue 1, Page 16-27, July 2026.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Development and evaluation of Sargassum polysaccharides-algal oil nanoemulsion for intranasal treatment of allergic rhinitis. [PDF]

Bioresour Bioprocess
Hung SY, Chan HW, Ku HH, Huang CH.
europepmc   +1 more source

PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses

British Journal of Pharmacology, Volume 183, Issue 13, Page 3619-3632, July 2026.
A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath, Katharina Inholz, Dennis Mink, Alicia Madel, Julia Koerner, Reinhold Horlacher, Michael Basler   +6 more
wiley   +1 more source

Ameliorating Effect of <i>Lavandula Angustifolia</i> on Experimental Autoimmune Encephalomyelitis Symptoms by Modulation of Immune Responses. [PDF]

Adv Biomed Res
Mahmoodi M, Jafarzadeh A, Aghaei A, Ramezani M, Zainodini N, Sedghy F, Pouya F.   +6 more
europepmc   +1 more source