Results 21 to 30 of about 20,678 (288)

P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress

open access: yesFrontiers in Physiology, 2020
Chronic stress leads to immunosuppression and induces splenocyte apoptosis. STAT3 is a transcription factor that regulates immunity and apoptosis; however, it is unclear whether the increased expression of phosphorylated STAT3 (p-STAT3) observed in ...
Manyu Song   +6 more
doaj   +1 more source

Selenium-chitosan alleviates the toxic effects of Zearalenone on antioxidant and immune function in mice

open access: yesFrontiers in Veterinary Science, 2022
This study assessed the protective effects of selenium-chitosan (SC) against antioxidant and immune function-related damage induced by zearalenone (ZEN) in mice. In total, 150 female mice were allotted to five groups for a 30-day study. Control mice were
Shunyi Qin   +4 more
doaj   +1 more source

Sensitive, Rapid, Quantitative and in Vitro Method for the Detection of Biologically Active Staphylococcal Enterotoxin Type E

open access: yesToxins, 2016
Staphylococcus aureus is a major bacterial cause of clinical infections and foodborne illnesses through its production of a group of enterotoxins (SEs) which cause gastroenteritis and also function as superantigens to massively activate T cells.
Reuven Rasooly   +2 more
doaj   +1 more source

Inhibitory Effect of Hydroxymethylfurfural in Viability of BALB/C Mice Splenocytes [PDF]

open access: yesPharmaceutical Sciences, 2019
Background: This study was designed to discover if hydroxymethylfurfural (HMF) exposure modifies cell proliferation and DNA damage in BALB/c mice splenocytes.
Sevda Saleh-Ghadimi   +3 more
doaj   +1 more source

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis [PDF]

open access: yesProceedings of the National Academy of Sciences, 2003
In sepsis, both necrotic and apoptotic cell death can occur. Apoptotic cells induce anergy that could impair the host response, whereas necrotic cells cause immune activation that might result in enhanced antimicrobial defenses. We determined whether adoptive transfer of apoptotic or necrotic cells impacted survival in a clinically
Richard S, Hotchkiss   +7 more
openaire   +2 more sources

Differential effect of culture epimastigotes and blood-form Trypamastigotes on normal mouse splenocyte responsiveness to mitogens

open access: yesMemorias do Instituto Oswaldo Cruz, 1986
Blood form trypomastigotes of the Y strain of T. cruzi, produced a strong inhibition of the blastogenic response to T and B cell mitogens, of the C3H/He, C57BLand BALB/cJ strains of mice, while culture epimastigotes of the Y strain kept in a medium that ...
L. E. Serrano, J. A. O'Daly
doaj   +1 more source

Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2020
Objective: To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation, Th1/Th2 balance, macrophage function, and the cytotoxic activity of natural killer (NK) cells.
Amin F Majdalawieh   +2 more
doaj   +1 more source

Splenocyte immunosuppression assay.

open access: yes, 2019
The splenocyte stimulated by LPS (A) or PMA/ionomycin (B) shows decreased proliferation rate when co-cultured with TMSC and cultured in TMSC-CM. Proliferation was significantly reduced by the number of TMSC and the concentration of TMSC-CM.
Chang Mo Moon (8066759)   +6 more
core   +1 more source

Microfluidic dissociation of spleen to recover immune cells for biotechnology and single cell analysis

open access: yesFrontiers in Immunology
IntroductionSplenocytes are important for various applications in medicine and biotechnology, but isolation methods are often limited by low yield, poor viability, bias towards certain cell subtypes, and degradation of surface marker expression. Here, we
Jeremy A. Lombardo   +7 more
doaj   +1 more source

Alternative to Animal Use for Detecting Biologically Active Staphylococcal Enterotoxin Type A

open access: yesToxins, 2018
Staphylococcal enterotoxins (SEs) are a food safety concern. Existing methods for biologically active SE detection rely on the emetic response in live kittens or monkeys.
Reuven Rasooly   +3 more
doaj   +1 more source

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