Results 21 to 30 of about 17,686 (257)

Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response

Asian Pacific Journal of Tropical Biomedicine, 2020
Objective: To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation, Th1/Th2 balance, macrophage function, and the cytotoxic activity of natural killer (NK) cells.
Amin F Majdalawieh, Jenna F Farraj, Ronald I Carr   +2 more
doaj   +1 more source

Streptococcus suis Serotype 2 Infection Induces Splenomegaly with Splenocyte Apoptosis

Microbiology Spectrum, 2022
Little is known about the damage to the important peripheral immune organ spleen caused by Streptococcus suis infection. In this study, we found that S. suis induced splenomegaly and lymphocyte disruption in spleens of mice.
Shujie Wang, Gang Wang, Yan-Dong Tang, Siqi Li, Lei Qin, Menghang Wang, Yong-Bo Yang, Marcelo Gottschalk, Xuehui Cai   +8 more
doaj   +1 more source

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis [PDF]

Proceedings of the National Academy of Sciences, 2003
In sepsis, both necrotic and apoptotic cell death can occur. Apoptotic cells induce anergy that could impair the host response, whereas necrotic cells cause immune activation that might result in enhanced antimicrobial defenses. We determined whether adoptive transfer of apoptotic or necrotic cells impacted survival in a clinically relevant sepsis ...
Richard S, Hotchkiss, Katherine C, Chang, Mitchell H, Grayson, Kevin W, Tinsley, Benjamin S, Dunne, Christopher G, Davis, Dale F, Osborne, Irene E, Karl   +7 more
openaire   +2 more sources

Microfluidic dissociation of spleen to recover immune cells for biotechnology and single cell analysis

Frontiers in Immunology
IntroductionSplenocytes are important for various applications in medicine and biotechnology, but isolation methods are often limited by low yield, poor viability, bias towards certain cell subtypes, and degradation of surface marker expression. Here, we
Jeremy A. Lombardo, David Zalazar, Marzieh Aliaghaei, Jered B. Haun, Jered B. Haun, Jered B. Haun, Jered B. Haun, Jered B. Haun   +7 more
doaj   +1 more source

Alternative to Animal Use for Detecting Biologically Active Staphylococcal Enterotoxin Type A

Toxins, 2018
Staphylococcal enterotoxins (SEs) are a food safety concern. Existing methods for biologically active SE detection rely on the emetic response in live kittens or monkeys.
Reuven Rasooly, Paula Do, Xiaohua He, Bradley Hernlem   +3 more
doaj   +1 more source

Genipin protects against sepsis via the inhibition of endoplasmic reticulum stress to attenuate splenocyte apoptosis

生物医学转化, 2023
Objective This study is undertaken to elucidate the protective effect and molecular mechanism of genipin against cecal ligation and puncture (CLP)-induced sepsis.
Luo Ning, Chen Guibing, Zhang Teng, Zhao Jie, Fu Jingnan, Lu Ning, Ma Tao   +6 more
doaj   +1 more source

Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets

Brain and Behavior
Objective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song, Bin Li, Ruoyi Guo, Yi Zhou, Yumei Xue, Li Guo   +5 more
doaj   +1 more source

Antibody response of mouse splenocytes using mixture of supernatants of thymocytes, adherent and non-adherent splenocytes: in-vitro immunization-II [PDF]

Journal of Korean Medical Science, 1990
We adapted one of the in-vitro immunization methods to induce antibody responses and confirmed the success of the immunization by enzyme-linked immunosorbent assay (ELISA) without hybridization. We have previously reported several methods of in-vitro immunization using different conditioned media.
D, Kim, G W, Noh, D H, Kim, O H, Kwon
openaire   +2 more sources

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source