Results 31 to 40 of about 17,686 (257)

Effect of ultra violet irradiation on the interplay between Th1 and Th2 lymphocytes

Frontiers in Pharmacology, 2015
Although UV radiation is used to treat several diseases, including rickets, psoriasis, eczema and jaundice, prolonged human exposure to UV radiation may result in acute and chronic health effects on the skin, eye and immune system.
Salma Y Abo Elnazar, Amany Abd-Elkader Ghazy, Hossam E. Ghoneim, AbdulRahman M. Taha, Amira M Abouelella   +4 more
doaj   +1 more source

Suppression of the Proliferation of Mouse Splenocytes by Pseudorabies Virus.

Journal of Veterinary Medical Science, 2000
Pseudorabies virus (PRV) infection in resistant swine caused immunosuppression which sometimes resulted in secondary infection by other viruses or bacteria. However the mechanism of the immunosuppression is not well understood. In this study, the effect of PRV on the immune system was examined in the mouse model.
TAKASHIMA, Yasuhiro, MATSUMOTO, Yasunobu, OTSUKA, Haruki   +2 more
openaire   +3 more sources

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis. [PDF]

PLoS ONE, 2012
Human amniotic epithelial cells (hAEC) have stem cell-like features and immunomodulatory properties. Here we show that hAEC significantly suppressed splenocyte proliferation in vitro and potently attenuated a mouse model of multiple sclerosis (MS ...
Yu Han Liu, Vijesh Vaghjiani, Jing Yang Tee, Kelly To, Peng Cui, Ding Yuan Oh, Ursula Manuelpillai, Ban-Hock Toh, James Chan   +8 more
doaj   +1 more source

Atrazine-induced apoptosis of splenocytes in BALB/C mice [PDF]

BMC Medicine, 2011
Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little understood.
Zheng Jing, Ren Rui, Gao Shuying, Wang Mingqiu, Zhang Xiaofeng, Zhang Yang   +5 more
openaire   +3 more sources

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Splenocyte proliferation, NK cell activation and cytokines production by extract of Scrophularia variegata; an in vitro study on mice spleen cells [PDF]

Research Journal of Pharmacognosy, 2016
Background and objectives:Scrophularia variegata M. Beib. (Scrophulariaceae) is a medicinal plant, used for various inflammatory diseases in Iranian Traditional Medicine. In the present study, we evaluated the immune modulation and antioxidant effects of
A. Azadmehr, R. Hajiaghaee, A.T. Molla Hassan, M. Jafari Vesiehsari, M. Oladnabidozin   +4 more
doaj  

NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-γ Production

Journal of Immunology Research, 2015
Background. Natural killer (NK) and natural killer T (NKT) cells contribute to the innate host defense but their role in bacterial sepsis remains controversial. Methods.
Eirini Christaki, Evdoxia Diza, Evangelos J. Giamarellos-Bourboulis, Nikoletta Papadopoulou, Aikaterini Pistiki, Dionysia-Irini Droggiti, Marianna Georgitsi, Alzbeta Machova, Dimitra Lambrelli, Nicolaos Malisiovas, Pavlos Nikolaidis, Steven M. Opal   +11 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. [PDF]

PLoS ONE, 2013
Mitochondrial transcription factor A (TFAM) is normally bound to and remains associated with mitochondrial DNA (mtDNA) when released from damaged cells.
Mark W Julian, Guohong Shao, Zachary C Vangundy, Tracey L Papenfuss, Elliott D Crouser   +4 more
doaj   +1 more source