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Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
ScienceThe minor spliceosome, which is responsible for the splicing of U12-type introns, comprises five small nuclear RNAs (snRNAs), of which only one is shared with the major spliceosome.
R. Bai +5 more
semanticscholar +1 more source
BioEssays, 1993
AbstractThe spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pre‐mRNA. A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA‐protein subunits, the U1, U2 and [U4/U6.U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non‐snRNP ...
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AbstractThe spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pre‐mRNA. A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA‐protein subunits, the U1, U2 and [U4/U6.U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non‐snRNP ...
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How Is Precursor Messenger RNA Spliced by the Spliceosome?
Annual Review of Biochemistry, 2019Splicing of the precursor messenger RNA, involving intron removal and exon ligation, is mediated by the spliceosome. Together with biochemical and genetic investigations of the past four decades, structural studies of the intact spliceosome at atomic ...
R. Wan, R. Bai, X. Zhan, Yigong Shi
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Architecture of the Spliceosome
Biochemistry, 2012Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human
Clarisse, van der Feltz +3 more
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Science, 1996
In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
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In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
openaire +2 more sources
Science, 1991
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
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In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
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Mechanisms of Spliceosomal Assembly
2014Pre-mRNA splicing is a key step for generating mature protein-coding mRNA. An RNA-protein complex known as the spliceosome carries out the chemistry of pre-mRNA splicing. However, several pre-spliceosomal intermediates are assembled on the pre-mRNA before the formation of the catalytically activated spliceosome.
Ni-Ting, Chiou, Kristen W, Lynch
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1997
Abstract Pre-mRNA splicing takes place within a large, highly dynamic complex designated the spliceosome. Spliceosomes are 50-60S, have a calculated molecular weight on the order of 3-5 × 106 kDa, and are estimated to be 40-60 nm in diameter (see 1, 2 for reviews). Among the best characterized of the spliceosomal components are the small
Robin Reed, Leon Palandjian
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Abstract Pre-mRNA splicing takes place within a large, highly dynamic complex designated the spliceosome. Spliceosomes are 50-60S, have a calculated molecular weight on the order of 3-5 × 106 kDa, and are estimated to be 40-60 nm in diameter (see 1, 2 for reviews). Among the best characterized of the spliceosomal components are the small
Robin Reed, Leon Palandjian
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Spliceosomal Proteins in Plants
2008The spliceosome is a large nuclear structure consisting of dynamically interacting RNAs and proteins. This chapter briefly reviews some of the known components and their interactions. Large-scale proteomics and gene expression studies may be required to unravel the many intricate mechanisms involved in splice site recognition and selection.
Y, Ru, B-B, Wang, V, Brendel
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Spliceosome Assembly and Composition
2007Cells control alternative splicing by modulating assembly of the pre-mRNA splicing machinery at competing splice sites. Therefore, a working knowledge of spliceosome assembly is essential for understanding how alternative splice site choices are achieved.
Arianne J, Matlin, Melissa J, Moore
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