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Nature Chemical Biology, 2007
The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.
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The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.
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Mechanistic insights into precursor messenger RNA splicing by the spliceosome
Nature reviews. Molecular cell biology, 2017Yigong Shi
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Mechanism for the initiation of spliceosome disassembly
NatureMatthias K. Vorländer +9 more
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Cryo-EM structure of a human spliceosome activated for step 2 of splicing
Nature, 2017K. Bertram +9 more
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