Results 201 to 210 of about 6,327 (242)

Tobramycin Affinity Tag Purification of Spliceosomes

Hans-Peter Vornlocher, Reinhard Lührmann, Klaus Hartmuth   +2 more
core   +1 more source

Competing 5’ splice sites of SRC1/HEH1 are marked for alternative splicing by U5 and U6 snRNAs during the B to Bact transition of the spliceosome

Banyal AK, Choudhuri P, Pillai BR, Varikkapulakkal A, Mishra SK.   +4 more
europepmc   +1 more source

Spliceosomes [PDF]

Current Biology, 2015
Melissa J Moore
exaly   +4 more sources

Scrutinizing spliceosomes [PDF]

Nature Reviews Genetics, 2018
Rebecca F Furlong
exaly   +4 more sources

Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense [PDF]

Cell, 2013
SummaryUsing the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis.
Phillip A Dumesic, Changbin Chen, Inés A Drinnenberg   +2 more
exaly   +3 more sources

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns

Nucleic Acids Research, 2021
Vertebrate genomes contain major (>99.5%) and minor (
Stephen Mieruszynski, Chaim M Roifman, Philippe M Campeau   +2 more
exaly   +2 more sources

Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2 [PDF]

Nucleic Acids Research, 2017
The DEAH-box NTPase Prp43 disassembles spliceosomes in co-operation with the cofactors Ntr1/Spp382 and Ntr2, forming the NTR complex. How Prp43 is regulated by its cofactors to discard selectively only intron-lariat spliceosomes (ILS) and defective ...
Ralf Ficner, Patrizia Fabrizio, Reinhard Lührmann   +2 more
exaly   +2 more sources

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Spliceosomes and snurposomes

Science, 1991
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
Joseph G Gall
exaly   +3 more sources

Architecture of the Spliceosome

Biochemistry, 2012
Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human
Clarisse, van der Feltz, Kelsey, Anthony, Axel, Brilot, Daniel A, Pomeranz Krummel   +3 more
openaire   +2 more sources

PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2

Cell Cycle, 2013
PDIP38 (polymerase delta interacting protein 38) was originally discovered as a protein that interacts with DNA polymerase δ and PCNA. PDIP38 is present in multiple intracellular locations and is a multifunctional protein that has been implicated in ...
Zhongtao Zhang, Zbigniew Darzynkiewicz, Ernest Y C Lee   +2 more
exaly   +1 more source