Results 141 to 150 of about 366,865 (319)

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Genome-wide analysis of gene expression and alternative splicing in human medulloblastoma

, 2010
Medulloblastoma is a malignant embryonal tumour of the cerebellum which most commonly affects children. A subset of tumours is thought to arise from cerebellar granule cell precursors (GCPs) that fail to undergo normal neuronal development, following ...
Menghi, F.
core  

Comparative analysis indicates that alternative splicing in plants has a limited role in functional expansion of the proteome

, 2009
Background Alternative splicing (AS) is a widespread phenomenon in higher eukaryotes but the extent to which it leads to functional protein isoforms and to proteome expansion at large is still a matter of debate.
Stiekema, W., Willem J Stiekema, Severing, E.I., Roeland CHJ van Ham, Ham, R.C.H.J., van, van Dijk, A.D.J., van Ham Roeland CHJ, Dijk, A.D.J., van, van Dijk Aalt DJ, van Ham, R.C.H.J., Severing Edouard I, Edouard I Severing, Aalt DJ van Dijk, Stiekema Willem J   +13 more
core   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

iCLIP predicts the dual splicing effects of TIA-RNA interactions

, 2010
The regulation of alternative splicing involves interactions between RNA-binding proteins and pre-mRNA positions close to the splice sites. T-cell intracellular antigen 1 (TIA1) and TIA1-like 1 (TIAL1) locally enhance exon inclusion by recruiting U1 ...
Nicholas M. Luscombe, Wang, Zheng, Zarnack, Kathi, Jernej Ule, Kayikci Melis, Rot, Gregor, Curk, Tomaz, Ule, Jernej, Zhen Wang, Luscombe, Nicholas M, Kathi Zarnack, Briese Michael, Zupan Blaž, Michael Briese, Melis Kayikci, Blaž Zupan, Ule Jernej, Wang Zhen, Zupan, Blaz, Zarnack Kathi, Luscombe Nicholas M., Briese, Michael, Curk Tomaž, Nicholas M Luscombe, Gregor Rot, Rot Gregor, Tomaž Curk, Kayikci, Melis   +27 more
core   +1 more source

A Versatile Microfluidic Extrusion‐Based Hydrogel Platform for Self‐Organization and Long‐Term Maintenance of Engineered 3D Lymphatic Endothelium

Advanced Healthcare Materials, EarlyView.
Microfluidic coaxial extrusion generates size‐controlled 3D lymphatic tubes from primary human dermal lymphatic endothelial cells in a defined four‐component matrix. These engineered vessels self‐organize into stable lymphatic endothelium, maintain selective macromolecular permeability for 30 days, and enable direct comparison with blood endothelial ...
Elsa Mazari‐Arrighi, Adeline Boyreau, Laura Chaillot, Wilfried Souleyreau, Laetitia Andrique, Pierre‐Olivier Guichet, Thomas Mathivet, Andreas Bikfalvi, Pierre Nassoy   +8 more
wiley   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

, 2011
There is a growing recognition of the importance of protein kinases in the control of alternative splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are needed.
Ursula Rauch, Jensen, Lars J, Jensen, Lars J., Bullock, AN, Szklarczyk, Damian, Doriano Fabbro, Filippakopoulos, P, Bracher, Franz, Stefan Knapp, Panagis Filippakopoulos, Oliver King, Bracher, F, Filippakopoulos, Panagis, Fedorov, Oleg, Szklarczyk, D, Oleg Fedorov, Huber, K, King, O, Bullock, Alex N., King, Oliver, Jensen, LJ, Knapp, Stefan, Andreas Eisenreich, Eisenreich, Andreas, Damian Szklarczyk, Huber, Kilian, Fabbro, Doriano, Fabbro, D, Kilian Huber, Knapp, S, Lars J. Jensen, Trappe, Jörg, Alex N. Bullock, Rauch, U, Jörg Trappe, Fedorov, O, Franz Bracher, Rauch, Ursula, Trappe, J, Eisenreich, A, Bullock, Alex N, Bullock, Alexander   +41 more
core   +1 more source

Get Spliced: Uniting Alternative Splicing and Arthritis

International Journal of Molecular Sciences
Immune responses demand the rapid and precise regulation of gene protein expression. Splicing is a crucial step in this process; ~95% of protein-coding gene transcripts are spliced during mRNA maturation. Alternative splicing allows for distinct functional regulation, as it can affect transcript degradation and can lead to alternative functional ...
Maurice J. H. van Haaren, Levina Bertina Steller, Sebastiaan J. Vastert, Jorg J. A. Calis, Jorg van Loosdregt   +4 more
openaire   +2 more sources

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, EarlyView.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source