Results 171 to 180 of about 603,390 (338)

Two Distinct Tumor-Derived, Parathyroid Hormone-Like Peptides Result from Alternative Ribonucleic Acid Splicing [PDF]

open access: bronze, 1988
Marguerite Mangin   +4 more
openalex   +1 more source

High‐Energy Femtosecond All‐Fiber Laser Systems in 1.7–1.8 μm Using a Normal‐Dispersion Tm‐Doped Fiber

open access: yesAdvanced Photonics Research, EarlyView.
High‐energy ultrafast all‐fiber lasers are demonstrated in the 1.7–1.8 μm range using a novel Tm‐doped fiber with depressed cladding for dispersion tailoring and short‐pass filtering. A parabolic core enhances optical gain, overcoming poor gain overlap in conventional depressed cladding fibers.
Shaoxiang Chen   +5 more
wiley   +1 more source

Chemical Approaches for Array Based Detection of Amyloids

open access: yesAdvanced Sensor Research, EarlyView.
Amyloids are protein aggregates with both pathological and functional roles. Their detection is challenged by structural polymorphism, isoform diversity, and dynamic aggregation behavior. This review presents chemical array‐based sensing strategies that address these complexities, emphasizing fluorescence and colorimetric methods, alongside ...
Paulo M. Simon, Yijia Xu, Amandeep Kaur
wiley   +1 more source

XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Elevated spliced form of X‐box–binding protein 1 (XBP1) correlates with unfavorable responses to endocrine therapy plus CDK4/6 inhibitors in HR+/HER2− advanced breast cancer. XBP1s facilitates cell proliferation and G1/S transition by transcriptionally activating SND1, thereby activating the E2F1 pathway.
Yuting Sang   +11 more
wiley   +1 more source

A Twist in the Diagnosis: Chronic Arthropathy Without Inflammation

open access: yes
Arthritis Care &Research, EarlyView.
María Á. Puche‐Larrubia   +3 more
wiley   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

open access: yesAdvanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang   +12 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

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