Results 181 to 190 of about 619,548 (333)

INFLUENCE OF BOLTED SPLICE CONNECTIONS ON THE GLOBAL BEHAVIOUR OF STEEL LATTICE TELECOMMUNICATION TOWERS

, 2023
A. Wojnar, К. Marszałek, Olena Chernieva, Lucjan Ślęczka, L. Śleczka   +4 more
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Here a Splice, There a Splice, Everywhere a Splice Splice

Journal of Biological Chemistry, 2005
openaire   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Dysregulation of SRSF11 in Cancer: Mechanistic Insights and Biomarker Potential for Diagnosis and Therapy. [PDF]

J Cancer
Jun Y, Shanshan L, Jingwen X, Yu H, Jianlong X, Qingfeng S.   +5 more
europepmc   +1 more source

Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells

, 2015
Ayesha A. Shafi, Vasanta Putluri, James M. Arnold, Efrosini Tsouko, Suman Kumar Maity, Justin M. Roberts, Cristian Coarfa, Daniel E. Frigo, Nagireddy Putluri, Arun Sreekumar, Nancy L. Weigel   +10 more
openalex   +2 more sources

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

RNA secondary structure and mountain plot for LAMB3 variants identified in EB patients (A) Wild-type RNA structure of the LAMB3 gene at the c.1977-1G > A splice acceptor site, showing a minimum free energy (MFE) of −132.75 kcal/mol.

Nancy Shehata (22258357), Babajan Banaganapalli (704628), Hadiah Bassam Al Mahdi (22258360), Shmoukh Alghuraibi (22258363), Mahmoud Younis (8831199), Sultana Abdulghani (22258366), Noor Ahmad Shaik (7889981), Zuhier Awan (10925105), Fahad Hakami (720371)   +8 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Alternative splicing contributes to plasticity and regulatory divergence in locally adapted house mice from the Americas. [PDF]

Mol Biol Evol
Phifer-Rixey M, Ward JR, Mack KL.
europepmc   +1 more source