Results 211 to 220 of about 603,390 (338)

Predicting nonsense-mediated mRNA decay from splicing events in sepsis using RNA-sequencing data. [PDF]

Life Sci Alliance
Shin J, Fredericks AM, Armstead BE, Ayala A, Cohen M, Fairbrother WG, Levy MM, Lillard KK, Raggi E, Nau GJ, Monaghan SF.   +10 more
europepmc   +1 more source

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

Saikosaponin‑D triggers cancer cell death by targeting the PIM1/c-Myc axis to reprogram oncogenic alternative splicing. [PDF]

Cell Death Discov
Zhang X, Li X, Zhang F, Yang D, Sun Q, Wei Y, Yan R, Xu D, Lin S, Yuan F, Wang W.   +10 more
europepmc   +1 more source

Chick α tropomyosin gene contains three sets of mutually exclusive alternatively spliced exons

, 1989
Marguerite Lemonnier, Domenico Libri, Marc Fiszman   +2 more
openalex   +2 more sources

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

Advanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao, Yifu Shen, Zhihui Xiao, Zhenbo Han, Xu Liu, Ao Cai, Yanan Tian, Guang Lian, Wenya Ma, Yining Liu, Rui Gong, Hanjing Li, Xiuxiu Wang, Zhongyu Ren, Naufal Zagidullin, Lei Yu, Ye Tian, Yu Liu, Zhenwei Pan, Baofeng Yang, Benzhi Cai   +20 more
wiley   +1 more source

Integrative analysis of Hub1 overexpression: driving transcriptional reprogramming and alternative splicing in Saccharomyces cerevisiae. [PDF]

BMC Genomics
Billah NMA, Khan U, Islam KMD, Abdul-Awal SM, Billah MM.   +4 more
europepmc   +1 more source

Functional analysis of alternatively spliced tyrosinase gene transcripts.

, 1988
Günter Müller, S Ruppert, E Schmid, G. Schütz   +3 more
openalex   +1 more source

In vivosplicing of the premRNAs from early region 3 of adenovirus-2: association of precursors, intermediates and products with hnRNP [PDF]

, 1986
Hélène Gallinaro, Annie Sittler, Monique Jacob   +2 more
openalex   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Integrating genetic regulation and schizophrenia-specific splicing quantitative expression with GWAS prioritizes novel risk genes for schizophrenia. [PDF]

Transl Psychiatry
Li X, Fan L, Zhao Y, Li Y, Wang J, Xu S, Xia J.   +6 more
europepmc   +1 more source