Results 211 to 220 of about 619,548 (333)

Table 2_Prognostic alternative mRNA splicing in lung adenocarcinoma.xlsx

Panke Su (22636301), Pei Xu (233476), Deying Xu (22636304)   +2 more
openalex   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Multidimensional regulatory roles and therapeutic applications of SRSF7 in cancer. [PDF]

Cell Death Discov
Li Y, Gao H, Zhang X, Sun F, Guo Y, Qiao X.   +5 more
europepmc   +1 more source

Selected genes characterized by heterogeneous expression of spliced and unspliced forms.

Daniil K. Lukyanov (20997755), Evgeniy S. Egorov (16478356), Valeriia V. Kriukova (11246519), Denis Syrko (22593444), Victor V. Kotliar (22593447), Kristin Ladell (122980), David A. Price (36138), Andre Franke (77511), Dmitry M. Chudakov (13360146)   +8 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Zhu ZM, Wu XM, Hu Y, Bian XL, Wang YQ, Zhu QN.   +5 more
europepmc   +1 more source

Data and code for TARDBP exitron splicing paper

Akihiro Sugai
openalex   +1 more source

trans-spliceosomal U6 RNAs of Crithidia fasciculata and Leptomonas seymouri: deviation from the conserved ACAGAG sequence and potential base pairing with spliced leader RNA.

, 1994
Guoliang Xu, Björn Wieland, Albrecht Bindereif   +2 more
openalex   +2 more sources

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

Additional file 3 of Two cases of TBL1XR1 heterozygous variants in children: a new splicing site variant identification and functional analysis through molecular docking and molecular dynamics simulation

Yaxue Xie, Z. Y. Zhang, Gang Zhu, Zhichao Li, Huiling Zhang, Jiaqi Zhang, Lin Wan, Guang Yang   +7 more
openalex   +1 more source