Results 221 to 230 of about 588,446 (356)
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song+37 more
wiley +1 more source
Splicing to keep splicing: A feedback system for cellular homeostasis and state transition. [PDF]
Guo Z, Zhang X, Li Y, Chen Y, Xu Y.
europepmc +1 more source
Organization of the Proteostasis Network of Membraneless Organelles
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim+6 more
wiley +1 more source
Alternative Splicing in Tumorigenesis and Cancer Therapy. [PDF]
Chen H, Tang J, Xiang J.
europepmc +1 more source
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu+10 more
wiley +1 more source
Swt21p Is Required for Nam8p-U1 snRNP Association and Efficient Pre-mRNA Splicing in <i>Saccharomyces cerevisiae</i>. [PDF]
Lin K+8 more
europepmc +1 more source
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu+6 more
wiley +1 more source