Results 81 to 90 of about 325,490 (342)
CD44 alternative splicing is a sensor of intragenic DNA methylation in tumors [PDF]
arXiv, 2019 DNA methylation (meDNA) is a suspected modulator of alternative splicing, while splicing in turn is involved in tumour formations nearly as frequently as DNA mutations. Yet, the impact of meDNA on tumorigenesis via its effect on splicing has not been thoroughly explored. Here, we find that HCT116 colon carcinoma cells inactivated for the DNA methylases
arxiv
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
The Application of Clinical Genetics, 2020 Camilo Andres Velandia-Piedrahita,1 Adrien Morel,2,* Dora Janeth Fonseca-Mendoza,2,* Victor Manuel Huertas-Quiñones,3– 5 David Castillo,6 Juan Diego Bonilla,7 Camilo José Hernandez-Toro,1 Marta Catalina Miranda-Fernández,1 ...
Velandia-Piedrahita CA +9 more
doaj
The Alternative Choice of Constitutive Exons throughout Evolution [PDF]
PLoS Genet 2007 3(11): e203, 2008 Alternative cassette exons are known to originate from two processes exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become alternative cassette exons during evolution. We compiled a dataset of orthologous exons from human and mouse that are constitutively spliced in
arxiv
Discrete Applied Mathematics, 1996 AbstractWe propose here a systematic formal study of the splicing operation introduced by Head as a model of recombinant behavior of DNA. We consider both simple and iterated splicing, with respect to a finite or an infinite set of splicing rules, in the latter case the whole set of rules constituting a regular language.
openaire +2 more sources
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Frontiers in Plant Science, 2019 Because of their sessile nature, plants have adopted varied strategies for growing and reproducing in an ever-changing environment. Control of mRNA levels and pre-mRNA alternative splicing are key regulatory layers that contribute to adjust and ...
Carlos Esteban Hernando +6 more
doaj +1 more source
arXiv, 2009 We introduce and study a natural variant of matroid amalgams. For matroids M(A) and N(B) such that M/(A-B)=N(B-A), we define a splice of M and N to be a matroid L on the union of A and B with L(B-A)=M and L/(A-B)=N. We show that splices exist for each such pair of matroids M and N; furthermore, there is a freest splice of M and N, which we call the ...
arxiv
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Getting the Entire Message: Progress in Isoform Sequencing
Frontiers in Genetics, 2019 The advent of second-generation sequencing and its application to RNA sequencing have revolutionized the field of genomics by allowing quantification of gene expression, as well as the definition of transcription start/end sites, exons, splice sites and ...
Simon A. Hardwick +5 more
doaj +1 more source