Results 71 to 80 of about 556,664 (302)

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]

, 2015
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego, Mendez, Aaron S, Peschek, Jirka, Walter, Peter   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Structural insights into lipid membrane binding by human ferlins

The EMBO Journal
Ferlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion.
Constantin Cretu, Aleksandar Chernev, Csaba Zoltán Kibédi Szabó, Vladimir Pena, Henning Urlaub, Tobias Moser, Julia Preobraschenski   +6 more
doaj   +1 more source

Structural Correlation Based Method for Image Forgery Classification and Localization

Applied Sciences, 2020
In the image forgery problems, previous works has been chiefly designed considering only one of two forgery types: copy-move and splicing. In this paper, we propose a scheme to handle both copy-move and splicing image forgery by concurrently classifying ...
Nam Thanh Pham, Jong-Weon Lee, Chun-Su Park   +2 more
doaj   +1 more source

Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways [PDF]

, 2019
The epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) control the epithelial-to-mesenchymal transition (EMT) splicing program in cancer. However, their role in breast cancer recurrence is unclear. In this study, we report that high levels
Badve, Sunil S., Goswami, Chirayu P., Gu, Xiaoping, Gu, Yuan, Gökmen‐Polar, Yesim, Janga, Sarath C., Nallamothu, Gouthami, Neelamraju, Yaseswini, Ryan, Michael, Vieth, Edyta   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Propagation of [D1,2]-type spliceosomal twin introns (stwintrons) in Hypoxylaceae and Xylariaceae fungi

Microbiology Spectrum
[D1,2] stwintrons consist of nested U2 introns, where an internal intron splits the 5′-donor of an external intron between its first and second nucleotide.
Erzsébet Fekete, Norbert Ág, Viktória Ág-Rácz, Alexandra Márton, Erzsébet Sándor, Claudio Scazzocchio, Michel Flipphi, Levente Karaffa   +7 more
doaj   +1 more source

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer

Frontiers in Genetics, 2023
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification.
Jennifer Lothion-Roy, Jennifer Lothion-Roy, Daisy B. Haigh, Daisy B. Haigh, Anna E. Harris, Anna E. Harris, Veronika M. Metzler, Mansour Alsaleem, Mansour Alsaleem, Mansour Alsaleem, Michael S. Toss, Michael S. Toss, Yousif Kariri, Yousif Kariri, Yousif Kariri, Atara Ntekim, Atara Ntekim, Brian D. Robinson, Francesca Khani, Lorraine J. Gudas, Cinzia Allegrucci, Cinzia Allegrucci, Victoria H. James, Victoria H. James, Srinivasan Madhusudan, Srinivasan Madhusudan, Melissa Mather, Richard D. Emes, Nathan Archer, Rupert G. Fray, Emad Rakha, Jennie N. Jeyapalan, Jennie N. Jeyapalan, Catrin S. Rutland, Nigel P. Mongan, Nigel P. Mongan, Nigel P. Mongan, Corinne L. Woodcock, Corinne L. Woodcock   +38 more
doaj   +1 more source

Alternative splicing regulation at tandem 3' splice sites [PDF]

Nucleic Acids Research, 2006
Alternative splicing (AS) constitutes a major mechanism creating protein diversity in humans. Previous bioinformatics studies based on expressed sequence tag and mRNA data have identified many AS events that are conserved between humans and mice.
Akerman, Martin, Mandel-Gutfreund, Yael
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source