Results 71 to 80 of about 366,865 (319)
, 2022 Contains all the files generated as part of the analysis of the following paper: Quantitative analysis of C. elegans transcripts by Nanopore direct-cDNA sequencing reveals terminal hairpins in non trans-spliced mRNAs. Bernard, et al.
Florian Bernard (12054248) +3 more
core +1 more source
Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays
Human GenomicsBackground TP53 variant classification benefits from the availability of large-scale functional data for missense variants generated using cDNA-based assays.
Cristina Fortuno +9 more
doaj +1 more source
Molecular Therapy: Nucleic AcidsPancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of tumors with growing incidence. Recent molecular analyses provided a precise picture of their genomic and epigenomic landscape. Splicing dysregulation is increasingly regarded as
Emilia Alors-Pérez +14 more
doaj +1 more source
A novel synonymous KMT2B variant in a patient with dystonia causes aberrant splicing
Molecular Genetics & Genomic Medicine, 2022 Background Heterozygous KMT2B variants are a common cause of dystonia. A novel synonymous KMT2B variant, c.5073C>T (p.Gly1691=) was identified in an individual with childhood‐onset progressive dystonia.
Bianca R. Grosz +13 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Structural insights into lipid membrane binding by human ferlins
The EMBO JournalFerlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion.
Constantin Cretu +6 more
doaj +1 more source
Structural Correlation Based Method for Image Forgery Classification and Localization
Applied Sciences, 2020 In the image forgery problems, previous works has been chiefly designed considering only one of two forgery types: copy-move and splicing. In this paper, we propose a scheme to handle both copy-move and splicing image forgery by concurrently classifying ...
Nam Thanh Pham +2 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Characterization of factors involved in the coupling of 3' end processing and splicing and in the 3' end formation of mRNA precursors [PDF]
, 2006 Eukaryotic mRNA precursors are processed at their 5’ and 3’ ends and are spliced prior to their export from the nucleus to the cytoplasm. Although all three processing reactions can be studied separately in vitro, they are coupled in vivo.
Kyburz Kooznetsoff, Andrea Martina
core +1 more source
Microbiology Spectrum[D1,2] stwintrons consist of nested U2 introns, where an internal intron splits the 5′-donor of an external intron between its first and second nucleotide.
Erzsébet Fekete +7 more
doaj +1 more source