Results 81 to 90 of about 366,865 (319)

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer

Frontiers in Genetics, 2023
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification.
Jennifer Lothion-Roy, Jennifer Lothion-Roy, Daisy B. Haigh, Daisy B. Haigh, Anna E. Harris, Anna E. Harris, Veronika M. Metzler, Mansour Alsaleem, Mansour Alsaleem, Mansour Alsaleem, Michael S. Toss, Michael S. Toss, Yousif Kariri, Yousif Kariri, Yousif Kariri, Atara Ntekim, Atara Ntekim, Brian D. Robinson, Francesca Khani, Lorraine J. Gudas, Cinzia Allegrucci, Cinzia Allegrucci, Victoria H. James, Victoria H. James, Srinivasan Madhusudan, Srinivasan Madhusudan, Melissa Mather, Richard D. Emes, Nathan Archer, Rupert G. Fray, Emad Rakha, Jennie N. Jeyapalan, Jennie N. Jeyapalan, Catrin S. Rutland, Nigel P. Mongan, Nigel P. Mongan, Nigel P. Mongan, Corinne L. Woodcock, Corinne L. Woodcock   +38 more
doaj   +1 more source

Chromatin and Splicing

, 2014
In the past several years, the relationship between chromatin structure and mRNA processing has been the source of significant investigation across diverse disciplines. Central to these efforts was an unanticipated nonrandom distribution of chromatin marks across transcribed regions of protein-coding genes.
Nazmul, Haque, Shalini, Oberdoerffer
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8

, 2009
The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J., Kershaw, Christopher J., O'Keefe, Raymond T., Barrass, J. David, Beggs, Jean D., O'Keefe, Raymond T.; id_orcid   +5 more
core   +1 more source

Operon conservation and the evolution of trans-splicing in the phylum Nematoda [PDF]

, 2006
The nematode Caenorhabditis elegans is unique among model animals in that many of its genes are cotranscribed as polycistronic pre-mRNAs from operons.
Mark L Blaxter, Blaxter, Mark L, Blaxter Mark L, David B Guiliano, Guiliano David B, Guiliano, David B   +5 more
core   +1 more source

Spliced leader RNA trans-splicing in dinoflagellates [PDF]

Proceedings of the National Academy of Sciences, 2007
Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Huan, Zhang, Yubo, Hou, Lilibeth, Miranda, David A, Campbell, Nancy R, Sturm, Terry, Gaasterland, Senjie, Lin   +6 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

, 2005
We have isolated the human protein SNEV as downregulated in replicatively senescent cells. Sequence homology to the yeast splicing factor Prp19 suggested that SNEV might be the orthologue of Prp19 and therefore might also be involved in pre-mRNA splicing.
Grillari, Johannes, Lamond, Angus I., Stadler, Guido, Voglauer, Regina, Eisenhaber, Frank, Löscher, Marlies, Lamond, Angus I.; id_orcid, Pokar, Marion, Ajuh, Paul, Grey, Martin, Fortschegger, Klaus, Ernst, Wolfgang, Katinger, Hermann, Chusainow, Janet   +13 more
core   +1 more source

Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay

Cell Genomics
Summary: The phenotypic impact of nonsense variants is determined by nonsense-mediated mRNA decay (NMD), which degrades transcripts with premature termination codons (PTCs).
Divya Kolakada, Rui Fu, Nikita Biziaev, Alexey Shuvalov, Mlana Lore, Amy E. Campbell, Michael A. Cortázar, Marcin P. Sajek, Jay R. Hesselberth, Neelanjan Mukherjee, Elena Alkalaeva, Zeynep H. Coban-Akdemir, Sujatha Jagannathan   +12 more
doaj   +1 more source