Results 51 to 60 of about 366,865 (319)

Splicing-derived epitopes and splicing-affected self-epitopes in SCLC patients.

, 2021
(A) Upper panel: Number of intron retentions per SCLC sample that impact the open reading frame. Lower panel: Number of candidate MHC-I binders per sample that are created (blue), i.e., splicing-derived neoepitopes, or potentially removed from the ORF by
Judith Pérez-Granado (11442479), Juan L. Trincado (11442473), Ferran Sanz (89706), Marina Reixachs-Solé (11442476), Tim Fugmann (11442482), Eduardo Eyras (3024), Jun Yokota (133873)   +6 more
core   +1 more source

PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signaling

Life Science Alliance
A triple osimertinib/calcineurin A/trametinib combination of treatment overcomes acquired resistance to EGFR TKI in EGFR-mutant lung adenocarcinoma cells that overexpress PPP3CB.
Sylvie Gazzeri, Nadiia Zubchuk, Elodie Montaudon, Fariba Nemati, Sarah Huot-Marchand, Giulia Berardi, Amelie Pucciarelli, Yassir Dib, Dylan Nerini, Christiane Oddou, Mylène Pezet, Laurence David-Boudet, Camille Ardin, Florence de Fraipont, Antonio Maraver, Nicolas Girard, Didier Decaudin, Anne-Claire Toffart, Beatrice Eymin   +18 more
doaj   +1 more source

Modeling Myeloid Malignancies Using Zebrafish

Frontiers in Oncology, 2017
Human myeloid malignancies represent a substantial disease burden to individuals, with significant morbidity and death. The genetic underpinnings of disease formation and progression remain incompletely understood.
Kathryn S. Potts, Kathryn S. Potts, Teresa V. Bowman, Teresa V. Bowman, Teresa V. Bowman   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

lmurba/splicing-pipelines-nf: v2.1

, 2022
Repository for the Anczukow-Lab splicing ...
PhilPalmer, Christina Chatzipantsiou, Vlad-Dembrovskyi, Brittany Angarola, Pablo Prieto, lmurba, Sangram K Sahu   +6 more
core   +1 more source

Splicing Misplaced [PDF]

Cell, 2005
Newly synthesized transcripts are usually spliced during transcription or immediately thereafter. So pre-mRNA splicing has been presumed to occur exclusively in the cell nucleus. In this issue of Cell, Denis et al. (2005) now report the presence of functional spliceosomes and signal-dependent pre-mRNA splicing in the cytoplasm of platelets.
Meshorer, Eran, Misteli, Tom
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hypoxia-induced alternative splicing in endothelial cells

, 2012
Background: Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues.
Weigand, Julia E., Julia E. Weigand (17017), Julia E Weigand, Pascal Gellert, Stefanie Dimmeler, Dimmeler, Stefanie, Jes-Niels Boeckel (145707), Pascal Gellert (145710), Gellert, Pascal, Jes-Niels Boeckel, Stefanie Dimmeler (134234), Boeckel, Jes-Niels   +11 more
core   +1 more source

Computing by splicing

Theoretical Computer Science, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gheorghe Paun, Grzegorz Rozenberg, Arto Salomaa   +2 more
openaire   +2 more sources

The pathobiology of splicing [PDF]

The Journal of Pathology, 2009
AbstractNinety‐four percent of human genes are discontinuous, such that segments expressed as mRNA are contained within exons and separated by intervening segments, called introns. Following transcription, genes are expressed as precursor mRNAs (pre‐mRNAs), which are spliced co‐transcriptionally, and the flanking exons are joined together to form a ...
Amanda J, Ward, Thomas A, Cooper
openaire   +2 more sources