Results 41 to 50 of about 556,664 (302)
Spliced-Leader trans-Splicing in Freshwater Planarians [PDF]
Molecular Biology and Evolution, 2005 trans-Splicing, in which a spliced-leader (SL) RNA is appended to the most 5' exon of independently transcribed pre-mRNAs, has been described in a wide range of eukaryotes, from protozoans to chordates. Here we describe trans-splicing in the freshwater planarian Schmidtea mediterranea, a free-living member of the phylum Platyhelminthes.
Ricardo M, Zayas +2 more
openaire +2 more sources
Diagnostics, 2022 Myelodysplastic syndromes (MDS) are considered to be diseases associated with splicing defects. A large number of genes involved in the pre-messenger RNA splicing process are mutated in MDS.
Nathalie Douet-Guilbert +3 more
doaj +1 more source
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]
, 2018 Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P. +11 more
core +3 more sources
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]
, 2014 Alternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative ...
Austin, Caroline A. +19 more
core +2 more sources
Biotechnology & Biotechnological Equipment, 2016 Cloning of coding sequence (CDS) is an important step for gene function research. Here, we reported a simple and efficient strategy for assembling multiple-exon into an intron-free CDS from genomic DNA (gDNA) by an isothermal recombination reaction-based
Wenxuan Chen +7 more
doaj +1 more source
Exon definitive regions for MPC1 microexon splicing and its usage for splicing modulation
Molecular Therapy: Nucleic Acids, 2023 Alternative splicing of microexons (3–30 base pairs [bp]) is involved in important biological processes in brain development and human cancers. However, understanding a splicing process of non-3x bp microexons is scarce.
Eunjin Koh, Daye Shin, Kyung-Sup Kim
doaj +1 more source
European Journal of Combinatorics, 2011 We introduce and study a natural variant of matroid amalgams. For matroids M(A) and N(B) such that M/(A-B)=N(B-A), we define a splice of M and N to be a matroid L on the union of A and B with L(B-A)=M and L/(A-B)=N. We show that splices exist for each such pair of matroids M and N; furthermore, there is a freest splice of M and N, which we call the ...
Bonin, Joseph E., Schmitt, William R.
openaire +3 more sources
Сахарный диабет, 2019 An erratum on «A synonymous variant in GCK gene as a cause of gestational diabetes mellitus» by Natalya A. Zubkova, Petr M. Rubtsov, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov (2019)
Natalia A. Zubkova +7 more
doaj +1 more source
Cells, 2021 The essential components of splicing are the splicing factors accumulated in nuclear speckles; thus, we studied how DNA damaging agents and A-type lamin depletion affect the properties of these regions, positive on the SC-35 protein.
Soňa Legartová +5 more
doaj +1 more source
Cells, 2021 Age-related macular degeneration (AMD) is a blinding disease for which most of the patients remain untreatable. Since the disease affects the macula at the center of the retina, a structure specific to the primate lineage, rodent models to study the ...
Laurence Klipfel +10 more
doaj +1 more source