Numerical prediction and experimental analysis of ends-together yarn splicing [PDF]
, 2016 Pneumatic yarn splicing is a technical process for joining two yarn ends together. The process involves injecting compressed air into a splicing chamber. The inlet pressure and chamber slope determine the main parameters affecting this process.
De Meulemeester, Simon +4 more
core +1 more source
Identification of Eight Spliceogenic Variants in BRCA2 Exon 16 by Minigene Assays
Frontiers in Genetics, 2018 Genetic testing of BRCA1 and BRCA2 identifies a large number of variants of uncertain clinical significance whose functional and clinical interpretations pose a challenge for genetic counseling.
Eugenia Fraile-Bethencourt +5 more
doaj +1 more source
CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin
Frontiers in Bioinformatics, 2022 Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of ...
Annelien Morlion +13 more
doaj +1 more source
Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56 419 completely sequenced and manually annotated full-length cDNAs [PDF]
, 2006 We report the first genome-wide identification and characterization of alternative splicing in human gene transcripts based on analysis of the full-length cDNAs.
Jun-ichi Takeda +65 more
core +2 more sources
Molecular Cell, 2007 A novel study in a recent issue of Molecular Cell (Shi and Manley, 2007) provides insight into a complex signaling pathway that controls the phosphorylation status of an SR-related protein that functions as a splicing repressor following heat shock-dependent dephosphorylation.
Guil, Sonia, Cáceres, Javier F.
openaire +2 more sources
Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing [PDF]
, 2015 Divergence of alternative splicing represents one of the major driving forces to shape phenotypic diversity during evolution. However, the extent to which these divergences could be explained by the evolving cis-regulatory versus trans-acting factors ...
Ballegeer, Marlies +4 more
core +2 more sources
Introns: the “dark matter” of the eukaryotic genome
Frontiers in Genetics, 2023 The emergence of introns was a significant evolutionary leap that is a major distinguishing feature between prokaryotic and eukaryotic genomes. While historically introns were regarded merely as the sequences that are removed to produce spliced ...
Kaitlin N. Girardini +4 more
doaj +1 more source
evolution, structure and function of metazoan splicing factor PRPF39 [PDF]
, 2019 In the yeast U1 snRNP the Prp39/Prp42 heterodimer is essential for early steps of spliceosome assembly. In metazoans no Prp42 ortholog exists, raising the question how the heterodimer is functionally substituted.
Bortoli, Francesca De +7 more
core +1 more source
Non-Coding RNA, 2022 Ubiquitous eukaryotic non-coding circular RNAs are involved in numerous co- and post-transcriptional regulatory mechanisms. Recently, we reported full-length intronic circular RNAs (flicRNAs) in Entamoeba histolytica, with 3′ss–5′ss ligation points and 5′
Jesús Alberto García-Lerena +3 more
doaj +1 more source
The Diverse Genomic Landscape of Diamond–Blackfan Anemia: Two Novel Variants and a Mini-Review
Children, 2023 Diamond–Blackfan anemia (DBA) is a ribosomopathy characterized by bone marrow erythroid hypoplasia, which typically presents with severe anemia within the first months of life. DBA is typically attributed to a heterozygous mutation in a ribosomal protein
Iordanis Pelagiadis +9 more
doaj +1 more source