Results 121 to 130 of about 208,874 (142)

The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

Jiang F, Boylan M, Maxwell DW, Qureshi WMS, Rowlands CF, Tenin G, Mitchell K, Stephen LA, Vasconcelos EJ, Wang D, Chen T, Zha J, Liu J, Althali N, Leordean DV, Gallagher MT, Basu B, Szymanska K, Veeraghanta A, Keavney B, Humphries MJ, Ellingford JM, Smith D, Johnson CA, O'Keefe RA, Roy S, Hentges KE.   +26 more
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Splice Factor

Science, 2008
Alternative splicing of transcripts generates significant functional diversity within genomes. This is particularly well illustrated by the CD45 gene, which undergoes regulated activation-dependent alternative splicing in lymphocytes to generate several functionally distinct isoforms. Oberdoerffer et al.
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Non-snRNP protein splicing factors

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993
III. Protein motifs in non-snRNP splicing factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 A. The RRM (RBD-CS) motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 B. The SR motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lamm, Gábor M., Lamond, Angus I.
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A PROTAC targets splicing factor 3B1

Cell Chemical Biology, 2021
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs.
Rodrigo A. Gama-Brambila, Jie Chen, Jun Zhou, Georg Tascher, Christian Münch, Xinlai Cheng   +5 more
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Abstract 1097: Knockdown of splicing factor ESRP1 affects multiple splicing factors

Cancer Research, 2015
Abstract Introduction: Tissue-specific alternative splicing (AS) is an important mechanism for regulating gene expression. Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2), two RNA-binding proteins (RBPs) that promote splicing, are potential candidates that contribute to breast cancer recurrence and resistance to ...
Yesim Gökmen-Polar, Yaseswini Neelamraju, Xiaoping Gu, Gouthami Nallamothu, Sarath C. Janga, Sunil Badve   +5 more
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Adaptive transcription-splicing resynchronization upon losing an essential splicing factor

Nature Ecology & Evolution, 2018
Essential genes form the core of a genome and are therefore thought to be indispensable for cellular viability. However, recent findings have challenged this notion in that cells may survive in the absence of some essential genes provided that relevant genetic modifiers are in existence.
Shang-Lin Chang, Hsuan-Kai Wang, Luh Tung, Tien-Hsien Chang   +3 more
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The Arabidopsis splicing factor SR1 is regulated by alternative splicing

Plant Molecular Biology, 2000
The serine-arginine (SR)-rich splicing factors play essential roles in general splicing and regulate alternative splice site utilization in a concentration-dependent manner. SR1 is a plant homologue of the human general/alternative splicing factor SF2/ASF. We report here that alternative splicing regulates SR1 itself.
G, Lazar, H M, Goodman
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Splicing factor mutations in AML

Blood, 2014
In this issue of Blood , Taskesen et al propose a novel subset of myeloid neoplasms that encompasses splicing factor (SF) mutation-positive refractory anemia with excess blasts (RAEB) and acute myeloid leukemia (AML), which is composed of 2 molecularly and clinically distinct subgroups ...
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Modelling the compartmentalization of splicing factors

Journal of Theoretical Biology, 2006
Splicing factor (SF) compartments, also known as speckles, are heterogeneously distributed compartments within the nucleus of eukaryotic cells that are enriched in pre-mRNA SFs. We derive a fourth-order aggregation-diffusion model that describes a possible mechanism underlying the organization of SFs into speckles. The model incorporates two hypotheses,
Carrero, G., Hendzel, M. J., de Vries, G.   +2 more
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Splicing Factor Mutations in Cancer

2016
Many cancers demonstrate aberrant splicing patterns that contribute to their development and progression. Recently, recurrent somatic mutations of genes encoding core subunits of the spliceosome have been identified in several different cancer types.
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