Results 131 to 140 of about 226,212 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

, 2011
There is a growing recognition of the importance of protein kinases in the control of alternative splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are needed.
Ursula Rauch, Jensen, Lars J, Jensen, Lars J., Bullock, AN, Szklarczyk, Damian, Doriano Fabbro, Filippakopoulos, P, Bracher, Franz, Stefan Knapp, Panagis Filippakopoulos, Oliver King, Bracher, F, Filippakopoulos, Panagis, Fedorov, Oleg, Szklarczyk, D, Oleg Fedorov, Huber, K, King, O, Bullock, Alex N., King, Oliver, Jensen, LJ, Knapp, Stefan, Andreas Eisenreich, Eisenreich, Andreas, Damian Szklarczyk, Huber, Kilian, Fabbro, Doriano, Fabbro, D, Kilian Huber, Knapp, S, Lars J. Jensen, Trappe, Jörg, Alex N. Bullock, Rauch, U, Jörg Trappe, Fedorov, O, Franz Bracher, Rauch, Ursula, Trappe, J, Eisenreich, A, Bullock, Alex N, Bullock, Alexander   +41 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Genome-wide survey and analysis of allele-specific mRNA splicing in human and mouse

, 2008
Includes abstract.Includes bibliographical references (leaves 125-145).This dissertation aims to examine allele-specific splicing in human and mouse using publicly available datasets.
Nembaware, Victoria Precious
core  

PSF (PTB-associated splicing factor) [PDF]

, 1999
Review on PSF (PTB-associated splicing factor), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL, JL Huret
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer

, 2014
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity.
Iliopoulos, D, Xie, J, Sanidas, I, Hu, L, Guo, A, Tsichlis, PN, Kottakis, F, Ezell, SA, Hatziapostolou, M, Polytarchou, C, Comb, MJ   +10 more
core   +1 more source

Biochemical characterization and three-dimensional structure analysis of the yeast cleavage and polyadenylation factor CPF [PDF]

, 2008
In eukaryotes, protein-encoding genes are transcribed in the nucleus by RNA polymerase II (RNAP II). Before the gene transcript (pre-mRNA) is transported to the cytoplasm and can function in translation, it has to undergo three specific maturation ...
Paguet, Bertrand
core   +1 more source