Results 121 to 130 of about 215,019 (165)

A Ralstonia solanacearum Effector Targets Splicing Factor SR34a to Reprogram Alternative Splicing and Regulate Plant Immunity. [PDF]

Plants (Basel)
Li Y, Kou S.
europepmc   +1 more source

Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer. [PDF]

Mol Cancer Res
Walker L, Duncan R, Adamson B, Kendall H, Brittain N, Luzzi S, Jones D, Chaytor L, Peel S, Crafter C, O'Neill DJ, Gaughan L.   +11 more
europepmc   +1 more source

Silencing serine/arginine-rich splicing factor 1 to induce apoptosis and autophagy-dependent cell death in cholangiocarcinoma through the correction of oncogenic splicing errors. [PDF]

Anat Cell Biol
Inpad C, Inpad C, Phetchahwang P, Pothipan P, Tangwiriyarotkul P, Hongsrichan N, Horpaopan S, Kaewkong W.   +7 more
europepmc   +1 more source

RNA splicing factor RBFOX2 is a key factor in the progression of cancer and cardiomyopathy. [PDF]

Clin Transl Med
Shen J, Shentu J, Zhong C, Huang Q, Duan S.   +4 more
europepmc   +1 more source

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Splicing factors: Insights into their regulatory network in alternative splicing in cancer

Cancer Letters, 2021
More than 95% of all human genes are alternatively spliced after transcription, which enriches the diversity of proteins and regulates transcript and/or protein levels. The splicing isoforms produced from the same gene can manifest distinctly, even exerting opposite effects.
Jun-Xian, Du, Gui-Qi, Zhu, Jia-Liang, Cai, Biao, Wang, Yi-Hong, Luo, Cong, Chen, Cheng-Zhe, Cai, Si-Jia, Zhang, Jian, Zhou, Jia, Fan, Wei, Zhu, Zhi, Dai   +11 more
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Splice Factor

Science, 2008
Alternative splicing of transcripts generates significant functional diversity within genomes. This is particularly well illustrated by the CD45 gene, which undergoes regulated activation-dependent alternative splicing in lymphocytes to generate several functionally distinct isoforms. Oberdoerffer et al.
openaire   +2 more sources

Modelling the compartmentalization of splicing factors

Journal of Theoretical Biology, 2006
Splicing factor (SF) compartments, also known as speckles, are heterogeneously distributed compartments within the nucleus of eukaryotic cells that are enriched in pre-mRNA SFs. We derive a fourth-order aggregation-diffusion model that describes a possible mechanism underlying the organization of SFs into speckles. The model incorporates two hypotheses,
Carrero, G., Hendzel, M. J., de Vries, G.   +2 more
openaire   +3 more sources

The Arabidopsis splicing factor SR1 is regulated by alternative splicing

Plant Molecular Biology, 2000
The serine-arginine (SR)-rich splicing factors play essential roles in general splicing and regulate alternative splice site utilization in a concentration-dependent manner. SR1 is a plant homologue of the human general/alternative splicing factor SF2/ASF. We report here that alternative splicing regulates SR1 itself.
G, Lazar, H M, Goodman
openaire   +2 more sources

A PROTAC targets splicing factor 3B1

Cell Chemical Biology, 2021
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs.
Rodrigo A. Gama-Brambila, Jie Chen, Jun Zhou, Georg Tascher, Christian Münch, Xinlai Cheng   +5 more
openaire   +2 more sources

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

Science, 1994
The opposing effects of SF2/ASF and heterogeneous nuclear ribonucleoprotein (hnRNP) A1 influence alternative splicing in vitro. SF2/ASF or hnRNP A1 complementary DNAs were transiently overexpressed in HeLa cells, and the effect on alternative splicing of several cotransfected reporter genes was measured.
Caceres, JF, Stamm, S, Helfman, DM Helfman, David M, Krainer, AR   +3 more
openaire   +2 more sources