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Non-snRNP protein splicing factors
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993III. Protein motifs in non-snRNP splicing factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 A. The RRM (RBD-CS) motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 B. The SR motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lamm, Gábor M., Lamond, Angus I.
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A PROTAC targets splicing factor 3B1
Cell Chemical Biology, 2021The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs.
Rodrigo A. Gama-Brambila +5 more
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Abstract 1097: Knockdown of splicing factor ESRP1 affects multiple splicing factors
Cancer Research, 2015Abstract Introduction: Tissue-specific alternative splicing (AS) is an important mechanism for regulating gene expression. Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2), two RNA-binding proteins (RBPs) that promote splicing, are potential candidates that contribute to breast cancer recurrence and resistance to ...
Yesim Gökmen-Polar +5 more
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Adaptive transcription-splicing resynchronization upon losing an essential splicing factor
Nature Ecology & Evolution, 2018Essential genes form the core of a genome and are therefore thought to be indispensable for cellular viability. However, recent findings have challenged this notion in that cells may survive in the absence of some essential genes provided that relevant genetic modifiers are in existence.
Shang-Lin Chang +3 more
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The Arabidopsis splicing factor SR1 is regulated by alternative splicing
Plant Molecular Biology, 2000The serine-arginine (SR)-rich splicing factors play essential roles in general splicing and regulate alternative splice site utilization in a concentration-dependent manner. SR1 is a plant homologue of the human general/alternative splicing factor SF2/ASF. We report here that alternative splicing regulates SR1 itself.
G, Lazar, H M, Goodman
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Splicing factor mutations in AML
Blood, 2014In this issue of Blood , Taskesen et al propose a novel subset of myeloid neoplasms that encompasses splicing factor (SF) mutation-positive refractory anemia with excess blasts (RAEB) and acute myeloid leukemia (AML), which is composed of 2 molecularly and clinically distinct subgroups ...
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Modelling the compartmentalization of splicing factors
Journal of Theoretical Biology, 2006Splicing factor (SF) compartments, also known as speckles, are heterogeneously distributed compartments within the nucleus of eukaryotic cells that are enriched in pre-mRNA SFs. We derive a fourth-order aggregation-diffusion model that describes a possible mechanism underlying the organization of SFs into speckles. The model incorporates two hypotheses,
Carrero, G. +2 more
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Splicing Factor Mutations in Cancer
2016Many cancers demonstrate aberrant splicing patterns that contribute to their development and progression. Recently, recurrent somatic mutations of genes encoding core subunits of the spliceosome have been identified in several different cancer types.
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Minimum Factorization Agreement of Spliced ESTs
2009Producing spliced EST sequences is a fundamental task in the computational problem of reconstructing splice and transcript variants, a crucial step in the alternative splicing investigation. Now, given an EST sequence, there can be several spliced EST sequences associated to it, since the original EST sequences may have different alignments against ...
BONIZZONI, PAOLA +4 more
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Alternative pre-mrna splicing: Factors involved in splice site selection
Journal of Cell Science, 1994The protein-coding regions of most vertebrate genes are split, giving rise to primary transcripts containing introns and exons; the latter must be spliced in the nucleus to form the mature mRNA, which then moves to the cytoplasm for translation. Pre-mRNA splicing, the process of intron removal and exon joining, represents an important function within ...
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