Results 291 to 300 of about 226,212 (308)
Some of the next articles are maybe not open access.
Splicing Factor Mutations in Cancer
2016Many cancers demonstrate aberrant splicing patterns that contribute to their development and progression. Recently, recurrent somatic mutations of genes encoding core subunits of the spliceosome have been identified in several different cancer types.
openaire +2 more sources
Adaptive transcription-splicing resynchronization upon losing an essential splicing factor
Nature Ecology & Evolution, 2018Essential genes form the core of a genome and are therefore thought to be indispensable for cellular viability. However, recent findings have challenged this notion in that cells may survive in the absence of some essential genes provided that relevant genetic modifiers are in existence.
Shang-Lin Chang +3 more
openaire +2 more sources
Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes
Current Pharmaceutical Design, 2016Splicing is an essential cellular process which is carried out by the spliceosome in order to remove the introns and join the exons present in pre-mRNA transcripts. A variety of spliceosomal mutations have been recently identified in the myelodysplastic syndromes (MDS), a heterogeneous group of hematopoietic stem cell malignancies, revealing a new ...
Bon Ham, Yip +4 more
openaire +2 more sources
Alternative pre-mrna splicing: Factors involved in splice site selection
Journal of Cell Science, 1994The protein-coding regions of most vertebrate genes are split, giving rise to primary transcripts containing introns and exons; the latter must be spliced in the nucleus to form the mature mRNA, which then moves to the cytoplasm for translation. Pre-mRNA splicing, the process of intron removal and exon joining, represents an important function within ...
openaire +2 more sources
Mechanistic insights into precursor messenger RNA splicing by the spliceosome
Nature Reviews Molecular Cell Biology, 2017Yigong Shi, Shi Yigong
exaly
RNA splicing factors as oncoproteins and tumour suppressors
Nature Reviews Cancer, 2016Heidi Dvinge +2 more
exaly
Splicing and transcription touch base: co-transcriptional spliceosome assembly and function
Nature Reviews Molecular Cell Biology, 2017Lydia Herzel +2 more
exaly
Context-dependent control of alternative splicing by RNA-binding proteins
Nature Reviews Genetics, 2014Xiang-Dong Fu +2 more
exaly
Functional consequences of developmentally regulated alternative splicing
Nature Reviews Genetics, 2011Auinash Kalsotra +2 more
exaly