Results 281 to 290 of about 226,212 (308)

Modelling the compartmentalization of splicing factors

Journal of Theoretical Biology, 2006
Splicing factor (SF) compartments, also known as speckles, are heterogeneously distributed compartments within the nucleus of eukaryotic cells that are enriched in pre-mRNA SFs. We derive a fourth-order aggregation-diffusion model that describes a possible mechanism underlying the organization of SFs into speckles. The model incorporates two hypotheses,
Carrero, G., Hendzel, M. J., de Vries, G.   +2 more
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The Arabidopsis splicing factor SR1 is regulated by alternative splicing

Plant Molecular Biology, 2000
The serine-arginine (SR)-rich splicing factors play essential roles in general splicing and regulate alternative splice site utilization in a concentration-dependent manner. SR1 is a plant homologue of the human general/alternative splicing factor SF2/ASF. We report here that alternative splicing regulates SR1 itself.
G, Lazar, H M, Goodman
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A PROTAC targets splicing factor 3B1

Cell Chemical Biology, 2021
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs.
Rodrigo A. Gama-Brambila, Jie Chen, Jun Zhou, Georg Tascher, Christian Münch, Xinlai Cheng   +5 more
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Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

Science, 1994
The opposing effects of SF2/ASF and heterogeneous nuclear ribonucleoprotein (hnRNP) A1 influence alternative splicing in vitro. SF2/ASF or hnRNP A1 complementary DNAs were transiently overexpressed in HeLa cells, and the effect on alternative splicing of several cotransfected reporter genes was measured.
Caceres, JF, Stamm, S, Helfman, DM Helfman, David M, Krainer, AR   +3 more
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Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

Immunological Reviews, 2014
SummaryDifferential splicing contributes to the vast complexity of mRNA transcripts and protein isoforms that are necessary for cellular homeostasis and response to developmental cues and external signals. The hematopoietic system provides an exquisite example of this.
Hahn, C., Venugopal, P., Scott, H., Hiwase, D.   +3 more
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Splicing factor mutations in AML

Blood, 2014
In this issue of Blood , Taskesen et al propose a novel subset of myeloid neoplasms that encompasses splicing factor (SF) mutation-positive refractory anemia with excess blasts (RAEB) and acute myeloid leukemia (AML), which is composed of 2 molecularly and clinically distinct subgroups ...
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Minimum Factorization Agreement of Spliced ESTs

2009
Producing spliced EST sequences is a fundamental task in the computational problem of reconstructing splice and transcript variants, a crucial step in the alternative splicing investigation. Now, given an EST sequence, there can be several spliced EST sequences associated to it, since the original EST sequences may have different alignments against ...
BONIZZONI, PAOLA, DELLA VEDOVA, GIANLUCA, Dondi, R, PIROLA, YURI, RIZZI, RAFFAELLA   +4 more
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Non-snRNP protein splicing factors

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993
III. Protein motifs in non-snRNP splicing factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 A. The RRM (RBD-CS) motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 B. The SR motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lamm, Gábor M., Lamond, Angus I.
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Abstract 1097: Knockdown of splicing factor ESRP1 affects multiple splicing factors

Cancer Research, 2015
Abstract Introduction: Tissue-specific alternative splicing (AS) is an important mechanism for regulating gene expression. Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2), two RNA-binding proteins (RBPs) that promote splicing, are potential candidates that contribute to breast cancer recurrence and resistance to ...
Yesim Gökmen-Polar, Yaseswini Neelamraju, Xiaoping Gu, Gouthami Nallamothu, Sarath C. Janga, Sunil Badve   +5 more
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A pan-cancer analysis of alternative splicing of splicing factors in 6904 patients

Oncogene, 2021
Great progress has been made in the investigation on mutation and expression of splicing factor. However, little is known on the role of alternative splicing of splicing factors across cancers. Here, we reported a pan-cancer analysis of alternative splicing of splicing factors spanning 6904 patients across 16 cancer types, and identified 167 splicing ...
Rui Cheng, Lixing Xiao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Chang Xu, Pingping Wang, Meng Luo, Mengyun Wang, Kexin Ma, Huimin Cao, Yan Huang, Xiaoyu Lin, Fenglan Pang, Yiqun Li, Qinghua Jiang   +15 more
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