Results 271 to 280 of about 369,265 (299)

Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

Immunological Reviews, 2014
SummaryDifferential splicing contributes to the vast complexity of mRNA transcripts and protein isoforms that are necessary for cellular homeostasis and response to developmental cues and external signals. The hematopoietic system provides an exquisite example of this.
Hahn, C., Venugopal, P., Scott, H., Hiwase, D.   +3 more
openaire   +4 more sources

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

Nature Immunology, 2006
By alternative splicing, different isoforms of the transmembrane tyrosine phosphatase CD45 are generated that either enhance or limit T cell receptor signaling. We report here that CD45 alternative splicing is regulated by cooperative action of the splice factor U2AF26 and the transcription factor Gfi1.
Heyd, F., Dam, G.B. ten, Moroy, T.
openaire   +3 more sources

[Oncogenic transcription factors as splicing regulators].

Medecine sciences : M/S, 2004
Oncogene activity ranges from transduction signals to transcription factors. Altered expression of oncogenes, either by chromosomal translocation, proviral insertion or point mutations, can lead to tumor formation. More specifically, data accumulated through the last two decades have shown that disregulation of oncogenic transcription factors can ...
Théoleyre, O., Baklouti, F.
openaire   +2 more sources

The physiology of alternative splicing

Nature Reviews Molecular Cell Biology, 2022
Alberto Kornblihtt
exaly  

Cycling splicing factors

Nature, 1994
openaire   +1 more source

RNA splicing dysregulation and the hallmarks of cancer

Nature Reviews Cancer, 2023
Robert K Bradley, Olga Anczukow
exaly  

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

From trans-splicing discovery and onwards, trypanosomes lead the way

Nature Reviews Molecular Cell Biology, 2022
Idálio J Viegas, Luisa Figueiredo
exaly  

Alternative splicing as a regulator of development and tissue identity

Nature Reviews Molecular Cell Biology, 2017
Francisco E Baralle, Jimena Giudice
exaly  

Mechanistic insights into precursor messenger RNA splicing by the spliceosome

Nature Reviews Molecular Cell Biology, 2017
Yigong Shi
exaly