Results 271 to 280 of about 226,212 (308)

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron. [PDF]

Exp Mol Med
Li Y, Chen Z, Xiao H, Liu Y, Zhao C, Yang N, Yuan C, Yan S, Li P.   +8 more
europepmc   +1 more source

The Arabidopsis thaliana core splicing factor PORCUPINE/SmE1 requires intron-mediated expression. [PDF]

PLoS One
Dikaya V, Rojas-Murcia N, Benstein RM, Eiserhardt WL, Schmid M.   +4 more
europepmc   +1 more source

Splicing factor 3b subunit 4 (SF3b4) is mediated by EP300 and CREBBP to promote colorectal cancer (CRC) proliferation by enhancing autophagy. [PDF]

Am J Cancer Res
Wu T, Xiao Z, Su B, Yan Z, Zhao Y, Huang C, Zhou L, Tian H, Zhang G.   +8 more
europepmc   +1 more source

Silencing serine/arginine-rich splicing factor 1 to induce apoptosis and autophagy-dependent cell death in cholangiocarcinoma through the correction of oncogenic splicing errors. [PDF]

Anat Cell Biol
Inpad C, Inpad C, Phetchahwang P, Pothipan P, Tangwiriyarotkul P, Hongsrichan N, Horpaopan S, Kaewkong W.   +7 more
europepmc   +1 more source

A Ralstonia solanacearum Effector Targets Splicing Factor SR34a to Reprogram Alternative Splicing and Regulate Plant Immunity. [PDF]

Plants (Basel)
Li Y, Kou S.
europepmc   +1 more source

Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer. [PDF]

Mol Cancer Res
Walker L, Duncan R, Adamson B, Kendall H, Brittain N, Luzzi S, Jones D, Chaytor L, Peel S, Crafter C, O'Neill DJ, Gaughan L.   +11 more
europepmc   +1 more source

Modulation of Splicing Factor Function and Alternative Splicing Outcomes

, 2022
Alternative RNA splicing is an important means of genetic control and transcriptome diversity. Alternative splicing events are frequently studied independently, and coordinated splicing controlled by common factors is often overlooked: The molecular mechanisms by which splicing regulators promote or repress specific pre-mRNA processing are still not ...
Chen, Steven Xiwei
openaire   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Splicing factors: Insights into their regulatory network in alternative splicing in cancer

Cancer Letters, 2021
More than 95% of all human genes are alternatively spliced after transcription, which enriches the diversity of proteins and regulates transcript and/or protein levels. The splicing isoforms produced from the same gene can manifest distinctly, even exerting opposite effects.
Jun-Xian, Du, Gui-Qi, Zhu, Jia-Liang, Cai, Biao, Wang, Yi-Hong, Luo, Cong, Chen, Cheng-Zhe, Cai, Si-Jia, Zhang, Jian, Zhou, Jia, Fan, Wei, Zhu, Zhi, Dai   +11 more
openaire   +2 more sources

Splice Factor

Science, 2008
Alternative splicing of transcripts generates significant functional diversity within genomes. This is particularly well illustrated by the CD45 gene, which undergoes regulated activation-dependent alternative splicing in lymphocytes to generate several functionally distinct isoforms. Oberdoerffer et al.
openaire   +2 more sources