Results 251 to 260 of about 369,265 (299)

SDS‐CRISPR for Single‐Nucleotide Variant Detection

Advanced Science, EarlyView.
Structure‐disruption‐sensitive CRISPR (SDS‐CRISPR) converts structural instability into single‐nucleotide precision, thereby overcoming mismatch tolerance in canonical Cas12a and enabling versatile diagnostics across DNA, RNA, and microRNA targets. When applied to rapid IDH1 mutation detection for glioma genotyping and integrated with lateral‐flow ...
Xin Guan, Chong Guo, Jiongyu Zhang, Rui Yang, Yerramsetti Ramachandra, Chengyu Hou, Minjie Pei, Shuo Zhang, Kurt T. Schalper, Xingye Liu, Qian Wu, Ketan R. Bulsara, Changchun Liu   +12 more
wiley   +1 more source

Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer. [PDF]

Mol Cancer Res
Walker L, Duncan R, Adamson B, Kendall H, Brittain N, Luzzi S, Jones D, Chaytor L, Peel S, Crafter C, O'Neill DJ, Gaughan L.   +11 more
europepmc   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading. [PDF]

iScience
Tseng PL, Sun W, Salem A, Alaklobie M, Macfarlane SC, Gad AKB, Collins MO, Erdmann KS.   +7 more
europepmc   +1 more source

The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle. [PDF]

PLoS Pathog
Faizo AAA, Bellward C, Hernandez-Lopez HR, Stevenson A, Gu Q, Graham SV.   +5 more
europepmc   +1 more source

RNA splicing factor RBFOX2 is a key factor in the progression of cancer and cardiomyopathy. [PDF]

Clin Transl Med
Shen J, Shentu J, Zhong C, Huang Q, Duan S.   +4 more
europepmc   +1 more source

Identification of new candidate drugs in myelodysplastic syndromes with splicing factor mutations by transcriptional profiling and connectivity map analysis. [PDF]

Br J Haematol
Sun T, Singh S, Wang HC, Lee J, Dolatshad H, Cheong PL, Higgs DR, Boultwood J, Pellagatti A.   +8 more
europepmc   +1 more source

Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12. [PDF]

Cell Biosci
Xie Y, Yang Z, Chen W, Zhong C, Li M, Zhang L, Cheng T, Deng Q, Wang H, Ju J, Du Z, Liang H.   +11 more
europepmc   +1 more source

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Splice Factor

Science, 2008
Alternative splicing of transcripts generates significant functional diversity within genomes. This is particularly well illustrated by the CD45 gene, which undergoes regulated activation-dependent alternative splicing in lymphocytes to generate several functionally distinct isoforms. Oberdoerffer et al.
openaire   +2 more sources

Non-snRNP protein splicing factors

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993
III. Protein motifs in non-snRNP splicing factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 A. The RRM (RBD-CS) motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 B. The SR motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lamm, Gábor M., Lamond, Angus I.
openaire   +3 more sources