Results 111 to 120 of about 965,525 (281)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Lexis: An R Class for Epidemiological Studies with Long-Term Follow-Up [PDF]
The Lexis class in the R package Epi provides an object-based framework for managing follow-up time on multiple time scales, which is an important feature of prospective epidemiological studies with long duration.
Bendix Carstensen, Martyn Plummer
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Effect of Nitrogen Fertilizer Dose and Application Timing on Yield and Nitrogen Use Efficiency of Irrigated Hybrid Rice under Semi-Arid Conditions [PDF]
, 2019 Nitrogen fertilizer is the major input in rice production and the optimum rate and application timing management assure profitability and sustainability of the production system.
Ametonou, F.Y. +5 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
ANALISIS KINERJA ALAT PENGERING SIMPLISIA JAHE SUMBER PANAS SINAR MATAHARI DENGAN CADANGAN PANAS KOMPOR BIOMASSA TIPE II [PDF]
, 2016 Simplisia adalah bahan alami yang digunakan sebagai bahan baku obat yang belum mengalami pengolahan tetapi sudah dikeringkan dengan kadar air maksimum 10%.
ROCHMAWATI, YESSY
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Revista de la Facultad de Ciencias Agrarias, 2019 Composting is an aerobic process used to treat organic residues, which results in a high quality product, able to be adopted as plant substrate or soil amendment. In the present study, the performance of compost on the germination and biomass of Lactuca
Iván Funes Pinter +5 more
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