Results 71 to 80 of about 96,969 (216)

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

Advanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis, Kaoutar Radi, Zifan Wang, Dennis M. Kochmann   +3 more
wiley   +1 more source

Efficiency of incomplete split-plot designs – a compromise between traditional split-plot designs and randomised complete block design

, 2008
The paper shows, how incomplete split-plot designs can be constructed from -designs and how they can be analysed. The incomplete split-plot design can be regarded as both a practical and statistical compromise between traditional split-plot design and randomised complete block design.
Kristensen, Kristian, Bigongiali, Frederica, Østergård, Hanne   +2 more
openaire   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Stereotactic radiotherapy for metastatic brain tumors: A comparative analysis of dose distributions among VMAT, Helical TomoTherapy, CyberKnife, Gamma Knife, and ZAP‐X

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract This study evaluates various radiotherapy techniques for treating metastatic brain tumor (BT), focusing on non‐coplanar volumetric modulated arc radiotherapy (NC‐VMAT), coplanar VMAT (C‐VMAT), Helical TomoTherapy (HT), CyberKnife (CK), Gamma Knife (GK), and ZAP‐X.
Toshihiro Suzuki, Masahide Saito, Ryutaro Nomura, Hikaru Nemoto, Naoto Yanagisawa, Ryuma Sawada, Zennosuke Mochizuki, Naoki Sano, Hiroshi Onishi, Hiroshi Takahashi   +9 more
wiley   +1 more source

Architected Lattices with a Topological Transition

Advanced Engineering Materials, EarlyView., 2023
This article develops topological metamaterials showing multidirectional two‐step deformation under compression by embedding contact‐enabled topological mechanisms into lattice structures. Experiments on 3D‐printed 2D and 3D lattices and finite element simulations are conducted to demonstrate the working principle of the topological metamaterials.
Shivam Agarwal, Lihua Jin
wiley   +1 more source

Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow. [PDF]

Org Process Res Dev
Takle MJ, Schrecker L, Deadman BJ, Dickhaut J, Wieja A, Hellgardt K, Mimi Hii KK.   +6 more
europepmc   +1 more source

A comparative analysis of deep learning architectures with data augmentation and multichannel input for locoregional breast cancer radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Studies on deep learning dose prediction increasingly focus on 3D models with multiple input channels and data augmentation, which increases the training time and thus also the environmental burden and hampers the ease of re‐training. Here we compare 2D and 3D U‐Net models with clinical accepted plans to evaluate the appropriateness of
Rosalie Klarenberg, Nienke L. M. Bakx, Coen W. Hurkmans   +2 more
wiley   +1 more source

Evaluation of Dental Arch Space Changes and the Need for a Space Maintainer After Unilateral Loss of Maxillary First Primary Molar: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Joshi VJ, Patel C, Patel MC, Fernandes MC, Makwani D, Patel F.   +5 more
europepmc   +1 more source

Monte Carlo modeling of radiation dose from radiation therapy with superficial x‐rays

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Superficial x‐rays (50–100 kVp) are used for treating non‐melanoma skin cancer and intraoperative radiation therapy (IORT). At these energies, the photoelectric effect significantly increases absorbed dose to bone compared to soft tissue.
Reham Barghash, Tiffany W. Martin, Amber R. Prebble, Del Leary   +3 more
wiley   +1 more source