Results 61 to 70 of about 10,156,002 (281)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Two-Factor Experiments with Split Units Constructed by Cyclic Designs and Square Lattice Designs

Revstat Statistical Journal, 2018
We consider nested row-column designs with split units for a two-factor experiment. The most optimal design in this case is that of using for the whole plots a Latin square while for the subplot treatments with a completely randomized design for each ...
Kazuhiro Ozawa , Iwona Mejza , Stanisław Mejza, Shinji Kuriki   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Designing fractional factorial split-plot experiments using integer programming

, 2011
Split-plot designs are commonly used in industrial experiments when there are hard-to-change and easy-to-change factors. Due to the number of factors and resource limitations, it is more practical to run a fractional factorial split-plot (FFSP) design ...
Capehart, Shay R.,, Kulahci, Murat,, Keha, Ahmet,, Keha, Ahmet, Kulahci, Murat, Montgomery, Douglas C.,, Douglas C. Montgomery, Shay R. Capehart, Murat Kulahci, Capehart, Shay R., Montgomery, Douglas C., Ahmet Keha   +11 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

D-Optimal Design for Mixture Amount Experiment Involving Split-Plot Design [PDF]

, 2021
A mixture amount experiment (MAE) is a design that depends on the proportions of the ingredients and the total amounts. The classical MAE contains the classical mixture experiment on each total amount.
Utami Dyah Syafitri, A. Muthiah Nur Angriany, Anik Djuraidah   +2 more
core   +1 more source

Response of lowland rice-ratooned rice-fluted pumpkin sequence to fertilizer in rainfed inland valley in derived savannah of Nigeria

Acta Agriculturae Slovenica, 2017
Trial was carried out at Federal University of Agriculture, Abeokuta, Nigeria between 2010 and 2012 to determine response of lowland rice-ratooned rice-fluted pumpkin sequence to fertilizer.
Sunday Ojo Adigbo, Joy N Odedina, Clement G Afolabi, Adebola A Osipitan, M Agbonlahor, T O Fabunmi, C O Adejuyigbe, F G Atanda, M L Nweke-Okoh   +8 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Efficiency of incomplete split-plot designs – a compromise between traditional split-plot designs and randomised complete block design

, 2008
The paper shows, how incomplete split-plot designs can be constructed from -designs and how they can be analysed. The incomplete split-plot design can be regarded as both a practical and statistical compromise between traditional split-plot design and ...
Bigongiali, Federica, Østergård, Hanne, Kristensen, Kristian   +2 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source