Results 71 to 80 of about 74,782 (138)

Circulating Metabolites Treat Human TMJ‐OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT Temporomandibular joint osteoarthritis (TMJ‐OA) is a progressive degenerative disorder, for which therapeutic interventions remain limited. The disruption of metabolic homeostasis plays a critical role in the pathogenesis and advancement of TMJ‐OA.
Bowen Meng   +19 more
wiley   +1 more source

BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single [PDF]

open access: yes, 2010
Aims: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP.
Campanilho-Marques, R.   +9 more
core  

Withdrawn: Impact of the RNF123 mutation on osteoclast differentiation in familial ankylosing spondylitis

open access: yesRheumatology &Autoimmunity, EarlyView.
Jin S, Ji X, Zhang L, Shi Y, Zhao D, Wan W. Impact of the RNF123 mutation on osteoclast differentiation in familial ankylosing spondylitis. Rheumatol & Autoimmun. 2023;1‐8. doi:10.1002/rai2.12102 Withdrawal: The above article, first published online 11th September 2024, on Wiley Online Library (wileyonlinelibrary.com), has been withdrawn by agreement ...
wiley   +1 more source

Successful Treatment of Refractory Sweet's Syndrome With Adalimumab in a Myelodysplastic Syndrome Patient

open access: yeseJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT We report a 69‐year‐old man diagnosed as myelodysplastic syndrome and administrated with azacitidine and selinexor treatment. Then he was revealed high fever and multiple tender erythematous papules involving his mouth, back, upper and lower extremities, which were diagnosed as Sweet's syndrome by skin biopsy.
Liya Ma   +7 more
wiley   +1 more source

Precision medicine in orthopaedics: A review of current technologies and future directions

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 2, Page 633-639, February 2026.
Abstract Purpose To synthesise the paradigm shift towards precision medicine in orthopaedics, where individual anatomical, biomechanical, molecular and kinematic characteristics are integrated into clinical decision‐making. Unlike traditional approaches applying uniform protocols, this review outlines how precision orthopaedics aims to tailor surgical ...
Patrick Sadoghi   +5 more
wiley   +1 more source

Chronic Rhinosinusitis and Autoimmune Diseases: A Comprehensive Large Population‐Based Analysis

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 1, February 2026.
ABSTRACT Objectives To evaluate associations between a wide variety of autoimmune diseases and chronic rhinosinusitis without nasal polyposis (CRSsNP), CRS with nasal polyposis (CRSwNP), and the need for endoscopic sinus surgery. Methods This is a multicenter retrospective study from January 1, 2010 to July 31, 2025 utilizing data from 106 healthcare ...
Robert E. Africa   +3 more
wiley   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas   +3 more
wiley   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami   +2 more
wiley   +1 more source

Temporomandibular disorders and neck disability in individuals with cervical disc herniation

open access: yesEuropean Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract The primary aim of this study was to investigate the prevalence and severity of temporomandibular disorders (TMDs), and temporomandibular joint (TMJ) pain in patients with cervical disc herniation. The secondary aim was to investigate the relationship between neck disability, neck pain, sociodemographic factors, TMD, and TMJ pain.
Turgay Altunalan   +3 more
wiley   +1 more source

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes

open access: yesImmunology, Volume 177, Issue 2, Page 398-412, February 2026.
ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Martha Nikopaschou   +6 more
wiley   +1 more source

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