Results 91 to 100 of about 317,847 (305)
Circular RNAs in hepatocellular carcinoma: Functions and implications
Cancer Medicine, 2018 At present, as hotspot members of the noncoding RNA network, circular RNAs (circRNAs) with distinct properties and diverse pathophysiological functions are being increasingly delineated.
Liyun Fu +4 more
doaj +1 more source
Molecules, 2016 Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks.
Kai-Kai Gong +4 more
doaj +1 more source
CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads
Advanced Healthcare Materials, EarlyView.In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura +4 more
wiley +1 more source
Eutrophication has no short-term effect on the Cymbastela stipitata holobiont
Frontiers in Microbiology, 2014 Levels of nitrogen in coastal areas have been rapidly increasing due to accumulative inputs of sewage and terrigenous sediments carrying fertilizers. Sponges have an immense filtering capacity and may be directly impacted (positively or negatively) by ...
Heidi M Luter +2 more
doaj +1 more source
Large-scale low-energy excitations in 3-d spin glasses
, 2000 We numerically extract large-scale excitations above the ground state in the 3-dimensional Edwards-Anderson spin glass with Gaussian couplings. We find that associated energies are O(1), in agreement with the mean field picture.
Houdayer, J. +2 more
core +2 more sources
Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
Advanced Healthcare Materials, EarlyView.A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Immunization by subcutaneous implants of polyester-polyurethane sponges coupled with antigen
Brazilian Journal of Medical and Biological Research, 1999 A new protocol is described for immunization of outbred Swiss mice. The procedure is based on subcutaneous implantation of antigen-coupled polyester-polyurethane sponges cut into disks of 10 mm in diameter vs 2 mm in thickness.
S.L. Lima +6 more
doaj +1 more source
Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application
Advanced Materials, EarlyView.This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong +12 more
wiley +1 more source
Biological activities of ethanolic extracts from deep-sea antarctic marine sponges [PDF]
, 2013 We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth ...
Ambrožič Avguštin, Jerneja +9 more
core +3 more sources