Results 121 to 130 of about 1,239,617 (330)

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Contribution of Spontaneous Mutations to Quantitative and Molecular Variation at the Highly Repetitive rDNA Locus in Yeast. [PDF]

Genome Biol Evol, 2023
Sharp NP, Smith DR, Driscoll G, Sun K, Vickerman CM, Martin SCT.   +5 more
europepmc   +1 more source

Explaining Quantum Spontaneous Symmetry Breaking [PDF]

, 2004
Two alternative accounts of quantum spontaneous symmetry breaking (SSB) are compared and one of them, the decompositional account in the algebraic approach, is argued to be superior for understanding quantum SSB.
Liu, Chuang, Emch, Gerard G.
core  

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Chromatin structure influences rate and spectrum of spontaneous mutations in Neurospora crassa. [PDF]

Genome Res, 2023
Villalba de la Peña M, Summanen PAM, Liukkonen M, Kronholm I.   +3 more
europepmc   +1 more source

Spontaneous Mutations of Bacteria

Annals of the Missouri Botanical Garden, 1945
The study of bacterial mutability is our only avenue of approach to problems of heredity in bacteria. This approach may be followed along two lines. Along one line one focuses his attention on the phenotypic differences between two strains which differ by one mutational step, in the endeavor to trace the reaction chains from the phenotype back'to the ...
openaire   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Corrigendum: Chromatin structure influences rate and spectrum of spontaneous mutations in Neurospora crassa. [PDF]

Genome Res, 2023
Villalba de la Peña M, Summanen PAM, Liukkonen M, Kronholm I.   +3 more
europepmc   +1 more source

Elevated rates and biased spectra of mutations in anaerobically cultured lactic acid bacteria

mBio
The rate, spectrum, and biases of mutations represent a fundamental force shaping biological evolution. Convention often attributes oxidative DNA damage as a major driver of spontaneous mutations.
Owen F. Hale, Michelle Yin, Megan G. Behringer   +2 more
doaj   +1 more source

Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes.

, 2009
Surprisingly different frequencies and patterns of K-ras mutations are observed in human adenocarcinomas of the pancreas, colorectum and lung. Their respective relationships with smoking are apparently paradoxical. We evaluated all the available types of
Real, F.X., Vineis, Paolo, Wark, P.A., Malats, N., Kampman, Ellen, Real, Francisco X., Vineis, P., Real, Francisco X, Crous-Bou, Marta, Crous-Bou, M., Wark, Petra A, Kampman, E., Wark, Petra A.; id_orcid, Porta, Miquel, Porta, M., Malats, Núria   +15 more
core   +1 more source