Cancer–immune coevolution dictated by antigenic mutation accumulation [PDF]
eLifeThe immune system is one of the first lines of defence against cancer. When effector cells attempt to suppress tumour, cancer cells can evolve methods of escape or inhibition.
Long Wang, Christo Morison, Weini Huang
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What can we infer about mutation calling by using time‐series mutation accumulation data and a Bayesian Mutation Finder? [PDF]
Ecology and EvolutionAccurate estimates of mutation rates derived from genome‐wide mutation accumulation (MA) data are fundamental to understanding basic evolutionary processes. The rapidly improving high‐throughput sequencing technologies provide unprecedented opportunities
Takahiro Maruki +3 more
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Mutation accumulation in
BMC Evolutionary Biology, 2010 Background The rate and fitness effects of mutations are key in understanding the evolution of every species. Traditionally, these parameters are estimated in mutation accumulation experiments where replicate lines are propagated in conditions that allow
Soares Helena +3 more
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Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation. [PDF]
Evol Ecol, 2022 All adaptive alleles in existence today began as mutations, but a common view in ecology, evolution, and genetics is that non-neutral mutations are much more likely to be deleterious than beneficial and will be removed by purifying selection. By dramatically limiting the effectiveness of selection in experimental mutation accumulation lines, multiple ...
Bao K, Melde RH, Sharp NP.
europepmc +3 more sources
Mutation Accumulation in an Asexual Relative of Arabidopsis. [PDF]
PLoS Genetics, 2017 Asexual populations experience weaker responses to natural selection, which causes deleterious mutations to accumulate over time. Additionally, stochastic loss of individuals free of deleterious mutations can lead to an irreversible increase in ...
John T Lovell +4 more
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Causes of variability in estimates of mutational variance from mutation accumulation experiments. [PDF]
Genetics, 2022 ABSTRACT Characteristics of the new phenotypic variation introduced via mutation have broad implications in evolutionary and medical genetics. Standardised estimates of this mutational variance, V M , span two orders of ...
Conradsen C, Blows MW, McGuigan K.
europepmc +6 more sources
Identification of natural product 3, 5-diiodotyrosine as APOBEC3B inhibitor to prevent somatic mutation accumulation and cancer progression [PDF]
Journal for ImmunoTherapy of Cancer, 2022 Background The development of cancer is largely dependent on the accumulation of somatic mutations, indicating the potential to develop cancer chemoprevention agents targeting mutation drivers.
Hongfei Wang +18 more
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Fitness Effects of Mutations: An Assessment of PROVEAN Predictions Using Mutation Accumulation Data. [PDF]
Genome Biol Evol, 2022 Abstract Predicting fitness in natural populations is a major challenge in biology. It may be possible to leverage fast-accumulating genomic data sets to infer the fitness effects of mutant alleles, allowing evolutionary questions to be addressed in any organism. In this paper, we investigate the utility of one such tool, called PROVEAN.
Sandell L, Sharp NP.
europepmc +5 more sources
Quantifying natural seasonal variation in mutation parameters with mutation accumulation lines [PDF]
Ecology and Evolution, 2018 AbstractMutations create novel genetic variants, but their contribution to variation in fitness and other phenotypes may depend on environmental conditions. Furthermore, natural environments may be highly heterogeneous. We assessed phenotypes associated with survival and reproductive success in over 30,000 plants representing 100 mutation accumulation ...
Matthew Rutter, Charles Fenster
exaly +3 more sources
Selection bias in mutation accumulation [PDF]
Evolution, 2021 Abstract Mutation accumulation (MA) experiments, in which de novo mutations are sampled and subsequently characterized, are an essential tool in understanding the processes underlying evolution.
Lindi M. Wahl, Deepa Agashe
openaire +2 more sources