Results 31 to 40 of about 1,757,426 (287)
mSystems, 2021 Trehalose biosynthesis pathway is a potential target for antifungal drug development, and trehalose 6-phosphate (T6P) accumulation is widely known to have toxic effects on cells.
Xin Chen +13 more
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mBio, 2019 Mutation accumulation experiments followed by whole-genome sequencing have revealed that, for several bacterial species, the rate of base-pair substitutions (BPSs) is not constant across the chromosome but varies in a wave-like pattern that is ...
Brittany A. Niccum +4 more
doaj +1 more source
Mutation accumulation and fitness in mutator subpopulations ofEscherichia coli [PDF]
Biology Letters, 2013 Bacterial populations in clinical and laboratory settings contain a significant proportion of mutants with elevated mutation rates (mutators). Mutators have a particular advantage when multiple beneficial mutations are needed for fitness, as in antibiotic resistance.
Ram P, Maharjan +5 more
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Muller's ratchet and mutational meltdowns [PDF]
, 1993 We extend our earlier work on the role of deleterious mutations in the extinction of obligately asexual populations. First, we develop analytical models for mutation accumulation that obviate the need for time-consuming computer simulations in certain ...
Lynch, M. +8 more
core +1 more source
Network Architecture and Mutational Sensitivity of the C. elegans Metabolome
Frontiers in Molecular Biosciences, 2018 A fundamental issue in evolutionary systems biology is understanding the relationship between the topological architecture of a biological network, such as a metabolic network, and the evolution of the network. The rate at which an element in a metabolic
Lindsay M. Johnson +4 more
doaj +1 more source
Mutation accumulation and the catastrophic senescence of the Pacific salmon [PDF]
Physical Review E, 1995 The bit-string model of biological aging is used to simulate the catastrophic senescence of Pacific Salmon. We have shown that reproduction occuring only once and at a fixed age is the only ingredient needed to explain the catastrophic senescence according the mutation accumulation theory.
Penna, T. J. P. +2 more
openaire +3 more sources
Deleterious mutation accumulation and the regeneration of genetic resources [PDF]
Proceedings of the National Academy of Sciences, 1998 The accumulation of mildly deleterious mutations accompanying recurrent regeneration of plant germ plasm was modeled under regeneration conditions characterized by different amounts of selection and genetic drift. Under some regeneration conditions (sample sizes ≥75 individuals and bulk harvesting of seed) mutation accumulation was negligible, but ...
Schoen, D.J. +2 more
openaire +5 more sources
Accumulation of Mutational Load at the Edges of a Species Range [PDF]
Molecular Biology and Evolution, 2018 Molecular Biology and Evolution, 35 (4)
Willi, Yvonne +3 more
openaire +6 more sources
Strains and mutation accumulation lines.
, 2023 The mutational processes dictating the accumulation of mutations in genomes are shaped by genetic background, environment and their interactions. Accurate quantification of mutation rates and spectra under drugs has important implications in disease ...
Jia-Xing Yue (3405950) +6 more
core +1 more source
Accumulation of mutations in sexual and asexual populations
Genetical Research, 1987 SummaryThe accumulation of beneficial and harmful mutations in a genome is studied by using analytical methods as well as computer simulation for different modes of reproduction. The modes of reproduction examined are biparental (bisexual, hermaphroditic), uniparental (selfing, automictic, asexual) and mixed (partial selfing, mixture of hermaphroditism
P, Pamilo, M, Nei, W H, Li
openaire +2 more sources