Results 51 to 60 of about 1,757,426 (287)

The genomic landscape of transposable elements in yeast hybrids is shaped by structural variation and genotype-specific modulation of transposition rate

eLife
Transposable elements (TEs) are major contributors to structural genomic variation by creating interspersed duplications of themselves. In return, structural variants (SVs) can affect the genomic distribution of TE copies and shape their load.
Mathieu Hénault, Souhir Marsit, Guillaume Charron, Christian R Landry   +3 more
doaj   +1 more source

Proteomic analysis of s-acylated proteins in human retinal pigment epithelial cells and the role of palmitoylation of Niemann-Pick type C1 protein in cholesterol transport

Frontiers in Aging Neuroscience, 2022
Palmitoylation is a dynamic process that regulates the activity of the modified proteins. Retinal pigment epithelial (RPE) cells play pivotal roles in the visual cycle and maintaining healthy photoreceptor cells.
Jia Kai Li, Yu Qing Rao, Siew Kwan Koh, Peiquan Zhao, Lei Zhou, Lei Zhou, Lei Zhou, Jing Li   +7 more
doaj   +1 more source

The role of mutation accumulation in HIV progression [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2005
The onset of AIDS is characterized by the collapse of the immune system after a prolonged asymptomatic period. The mechanistic basis of this disease progression has remained obscure, hindering the development of effective therapies. Here I present a mechanism that underlies the deterioration of the immune system during HIV infection.
openaire   +2 more sources

Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation

G3: Genes, Genomes, Genetics, 2016
We accumulated mutations for 1952 generations in 79 initially identical, haploid lines of the fission yeast Schizosaccharomyces pombe, and then performed whole-genome sequencing to determine the mutation rates and spectrum.
Megan G. Behringer, David W. Hall
doaj   +1 more source

Spontaneous rate of clonal single nucleotide mutations in Daphnia galeata.

PLoS ONE, 2022
Mutations are the ultimate source of heritable variation and therefore the fuel for evolution, but direct estimates of mutation rates exist only for few species. We estimated the spontaneous single nucleotide mutation rate among clonal generations in the
Markus Pfenninger, Halina Binde Doria, Jana Nickel, Anne Thielsch, Klaus Schwenk, Mathilde Cordellier   +5 more
doaj   +1 more source

simulation code for mutation accumulation in selfing populations

, 2021
C++ code for simulation of mutation accumulation in selfing populations. The related paper is: Xu, Kuangyi. Mutation accumulation in inbreeding populations under evolution of the selfing rate.
Kuangyi Xu
core   +1 more source

Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae

G3: Genes, Genomes, Genetics, 2016
Estimates of the fitness effects of spontaneous mutations are important for understanding the adaptive potential of species. Here, we present the results of mutation accumulation experiments over 265–512 sequential generations in four species of marine ...
Marc Krasovec, Adam Eyre-Walker, Nigel Grimsley, Christophe Salmeron, David Pecqueur, Gwenael Piganeau, Sophie Sanchez-Ferandin   +6 more
doaj   +1 more source

The rate and molecular spectrum of mutation are selectively maintained in yeast

Nature Communications, 2021
How natural selection shapes the rate and molecular spectrum of mutations is debated. Yeast mutation accumulation experiments identify a gene promoting mutagenesis and show stabilizing selection maintaining the mutation rate above the drift barrier ...
Haoxuan Liu, Jianzhi Zhang
doaj   +1 more source

Low base‐substitution mutation rate and predominance of insertion‐deletion events in the acidophilic bacterium Acidobacterium capsulatum

Ecology and Evolution, 2021
Analyses of spontaneous mutation have shown that total genome‐wide mutation rates are quantitatively similar for most prokaryotic organisms. However, this view is mainly based on organisms that grow best around neutral pH values (6.0–8.0). In particular,
Sibel Kucukyildirim, Samuel F. Miller, Michael Lynch   +2 more
doaj   +1 more source

Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli

mBio, 2019
High-level resistance often evolves when populations of bacteria are exposed to antibiotics, by either mutations or horizontally acquired genes. There is also variation in the intrinsic resistance levels of different bacterial strains and species that is
Otmane Lamrabet, Mikaël Martin, Richard E. Lenski, Dominique Schneider   +3 more
doaj   +1 more source