Results 61 to 70 of about 1,757,426 (287)
saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus. [PDF]
PLoS ONE, 2012 Mutation of the staphylococcal accessory regulator (sarA) limits biofilm formation in diverse strains of Staphylococcus aureus, but there are exceptions. One of these is the commonly studied strain Newman.
Lara N Mrak +7 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana
BMC Plant Biology, 2022 Background MicroRNAs (miRNAs) and other epigenetic modifications play fundamental roles in all eukaryotic biological processes. DNA damage repair is a key process for maintaining the genomic integrity of different organisms exposed to diverse stresses ...
Juan Du +8 more
doaj +1 more source
Accumulation of deleterious mutations in the domestic yak genome [PDF]
Animal Genetics, 2018 SummaryDeleterious mutations play an important functional role, affecting trait phenotypes in ways that decrease the fitness of organisms. Estimating the frequency of occurrence and abundance has been a topic of much interest, especially in crops and livestock.
X, Xie +9 more
openaire +2 more sources
THE ROLE OF DNA REPLICATION TIMING IN GERMLINE MUTATION ACCUMULATION [PDF]
, 2020 99 pagesDNA replication timing is a highly regulated, cell type-specific process that is associated with mutation accumulation. The developmental plasticity of replication timing complicates this relationship, however.
Hulke, Michelle Lauren
core +1 more source
Population-based statistical inference for temporal sequence of somatic mutations in cancer genomes
BMC Medical Genomics, 2018 Background It is well recognized that accumulation of somatic mutations in cancer genomes plays a role in carcinogenesis; however, the temporal sequence and evolutionary relationship of somatic mutations remain largely unknown.
Je-Keun Rhee, Tae-Min Kim
doaj +1 more source
SMAL: A Resource of Spontaneous Mutation Accumulation Lines [PDF]
Molecular Biology and Evolution, 2014 Mutation is the ultimate source of genetic variation and evolution. Mutation accumulation (MA) experiments are an alternative approach to study de novo mutation events directly. We have constructed a resource of Spontaneous Mutation Accumulation Lines (SMAL; http://cefg.uestc.edu.cn/smal), which contains all the current publicly available MA lines ...
Wen, Wei +6 more
openaire +2 more sources
Role of mutation in pseudomonas aeruginosa biofilm development.
, 2009 The survival of bacteria in nature is greatly enhanced by their ability to grow within surface-associated communities called biofilms. Commonly, biofilms generate proliferations of bacterial cells, called microcolonies, which are highly recalcitrant, 3 ...
Collins, Samuel L. +11 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
Muver, a computational framework for accurately calling accumulated mutations
BMC Genomics, 2018 Background Identification of mutations from next-generation sequencing data typically requires a balance between sensitivity and accuracy. This is particularly true of DNA insertions and deletions (indels), that can impart significant phenotypic ...
Adam B. Burkholder +5 more
doaj +1 more source