Results 41 to 50 of about 1,757,426 (287)
Vital Rates from the Action of Mutation Accumulation [PDF]
Journal of Population Ageing, 2009 New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to questions in the biodemography of longevity, including proposed explanations of Gompertz hazards and mortality plateaus ...
Wachter, Kenneth W. +2 more
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Genome-Wide Mutation Rate Response to pH Change in the Coral Reef Pathogen
mBio, 2017 Recent application of mutation accumulation techniques combined with whole-genome sequencing (MA/WGS) has greatly promoted studies of spontaneous mutation.
Chloe Strauss +4 more
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Markov models for accumulating mutations [PDF]
Biometrika, 2009 We introduce and analyze a waiting time model for the accumulation of genetic changes. The continuous-time conjunctive Bayesian network is defined by a partially ordered set of mutations and by the rate of fixation of each mutation. The partial order encodes constraints on the order in which mutations can fixate in the population, shedding light on the
N. Beerenwinkel, S. Sullivant
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Genome Biology, 2021 Background Elevated temperatures can cause physiological, biochemical, and molecular responses in plants that can greatly affect their growth and development. Mutations are the most fundamental force driving biological evolution.
Zhaogeng Lu +11 more
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Accumulating waves of random mutations before fixation
Physical Review E, 2022 Abstract Mutations provide variation for evolution to emerge. A quantitative analysis of how mutations arising in single individuals expand and possibly fixate in a population is essential for studying evolutionary processes. While it is intuitive to expect that a continuous influx of mutations will lead to a continuous flow of ...
Marius Moeller +2 more
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Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. [PDF]
, 2016 Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C +7 more
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Spontaneous mutations and the origin and maintenance of quantitative genetic variation
eLife, 2016 Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natural selection.
Wen Huang +6 more
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The mutational meltdown in asexual populations [PDF]
, 1993 Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of
Lynch, M. +6 more
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Hierarchical Assessment of Mutation Properties in Daphnia magna
G3: Genes, Genomes, Genetics, 2018 Understanding the context-dependence of spontaneous mutations is crucial to predicting evolutionary trajectories. In this experiment, the impact of genetic background and trait-type on mutational susceptibility was investigated.
Sarah Eberle +6 more
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Accumulation of beneficial mutations in one dimension
Physical Review E, 2011 When beneficial mutations are relatively common, competition between multiple unfixed mutations can reduce the rate of fixation in well-mixed asexual populations. We introduce a one dimensional model with a steady accumulation of beneficial mutations. We find a transition between periodic selection and multiple-mutation regimes.
Otwinowski, Jakub, Boettcher, Stefan
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