Results 21 to 30 of about 1,757,426 (287)
Pathogens, 2023 The persistence of a high-risk Human papillomavirus (HPV-HR) infection of the cervix results in different manifestations of lesions depending on the immunologic capacity of the host.
Eliza Pizarro Castilha +6 more
doaj +1 more source
The causes of mutation accumulation in mitochondrial genomes [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2009 A fundamental observation across eukaryotic taxa is that mitochondrial genomes have a higher load of deleterious mutations than nuclear genomes. Identifying the evolutionary forces that drive this difference is important to understanding the rates and patterns of sequence evolution, the efficacy of natural selection, the maintenance of sex and ...
Maurine, Neiman, Douglas R, Taylor
openaire +2 more sources
New complexities of SOS-induced “untargeted” mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing [PDF]
DNA Repair, 2020 Haixu Tang +2 more
exaly +2 more sources
Mutation accumulation and the formation of range limits [PDF]
Biology Letters, 2015 Abstract The dynamics of range formation are important for understanding and predicting species distributions. Here, we focus on a process that has thus far been overlooked in the context of range formation; the accumulation of mutation load.
Roslyn C, Henry +2 more
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Frontiers in Genetics, 2021 Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of ...
Stewart Frankel, Blanka Rogina
doaj +1 more source
Metapopulation extinction caused by mutation accumulation [PDF]
Proceedings of the National Academy of Sciences, 2001 Theory suggests that the risk of extinction by mutation accumulation can be comparable to that by environmental stochasticity for an isolated population smaller than a few thousand individuals. Here we show that metapopulation structure, habitat loss or fragmentation, and environmental stochasticity can be expected to greatly accelerate the ...
K, Higgins, M, Lynch
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Mutation testing on an object-oriented framework: An experience report [PDF]
, 2011 This is the preprint version of the article - Copyright @ 2011 ElsevierContext The increasing presence of Object-Oriented (OO) programs in industrial systems is progressively drawing the attention of mutation researchers toward this paradigm.
Sergio Segura +11 more
core +1 more source
Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life
G3: Genes, Genomes, Genetics, 2016 Mutations are the ultimate source of variation used for evolutionary adaptation, while also being predominantly deleterious and a source of genetic disorders.
Way Sung +6 more
doaj +1 more source
Mutation independently affects reproductive traits and dauer larvae development in mutation accumulation lines of Caenorhabditis elegans [PDF]
, 2017 Developmental decisions are important in organismal fitness. For the nematode Caenorhabditis elegans, which is naturally found in the ephemeral food patches formed by rotting plant material, correctly committing to dauer or non-dauer larval development ...
Harvey, S., Hills, A., Green, J.
core +1 more source
G3: Genes, Genomes, Genetics, 2016 Mycobacterium smegmatis is a bacterium that is naturally devoid of known postreplicative DNA mismatch repair (MMR) homologs, mutS and mutL, providing an opportunity to investigate how the mutation rate and spectrum has evolved in the absence of a highly ...
Sibel Kucukyildirim +5 more
doaj +1 more source