Results 81 to 90 of about 1,757,426 (287)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Limited Mutation-Rate Variation Within the Paramecium aurelia Species Complex

G3: Genes, Genomes, Genetics, 2018
Mutation is one of the most fundamental evolutionary forces. Studying variation in the mutation rate within and among closely-related species can help reveal mechanisms of genome divergence, but such variation is unstudied in the vast majority of ...
Hongan Long, Thomas G. Doak, Michael Lynch   +2 more
doaj   +1 more source

Mutation accumulation in a selfing population: consequences of different mutation rates between selfers and outcrossers. [PDF]

PLoS ONE, 2012
Currently existing theories predict that because deleterious mutations accumulate at a higher rate, selfing populations suffer from more intense genetic degradation relative to outcrossing populations.
Shin-ichiro Nakayama, Shoi Shi, Masaki Tateno, Masakazu Shimada, K Ryo Takahasi   +4 more
doaj   +1 more source

Adaptive mutation with fitness and allele distribution correlation for genetic algorithms [PDF]

, 2006
Copyright @ 2006 ACMIn this paper, a new gene based adaptive mutation scheme is proposed for genetic algorithms (GAs), where the information on gene based fitness statistics and on gene based allele distribution statistics are correlated to explicitly ...
Yang, S, Shengxiang Yang, Yang, Shengxiang, Uyar, S   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster. [PDF]

PLoS Genetics, 2010
Using a transgenic mouse model harboring a mutation reporter gene that can be efficiently recovered from genomic DNA, we previously demonstrated that mutations accumulate in aging mice in a tissue-specific manner.
Ana Maria Garcia, R Brent Calder, Martijn E T Dollé, Martha Lundell, Pankaj Kapahi, Jan Vijg   +5 more
doaj   +1 more source

Accumulation of Spontaneous Mutations in the CiliateTetrahymena thermophila [PDF]

Genetics, 2013
AbstractKnowledge of the rate and fitness effects of mutations is essential for understanding the process of evolution. Mutations are inherently difficult to study because they are rare and are frequently eliminated by natural selection. In the ciliate Tetrahymena thermophila, mutations can accumulate in the germline genome without being exposed to ...
Hong-An Long, Tiago Paixão, Ricardo B. R. Azevedo, Rebecca A. Zufall   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

SCP2 mutations and neurodegeneration with brain iron accumulation [PDF]

Neurology, 2015
Mutations in PANK2 , PLA2G6 , C19orf12 , FA2H , ATP13A2 , WDR45 , COASY , FTL , CP , and DCAF17 cause neurodegeneration with brain iron accumulation (NBIA), but the genetic etiology remains undefined in many patients. We report the second patient with sterol carrier protein x (SCPx) deficiency presenting with adult-onset spinocerebellar ataxia and ...
Horvath R, Lewis-Smith D, Douroudis K, Duff J, Keogh M, Pyle A, Fletcher N, Chinnery PF   +7 more
openaire   +3 more sources