Results 91 to 100 of about 1,757,426 (287)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Intra-organ variation in age-related mutation accumulation in the mouse. [PDF]

PLoS ONE, 2007
Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age much more rapidly in the small intestine than in the brain.
Rita A Busuttil, Ana Maria Garcia, Robert L Reddick, Martijn E T Dollé, Robert B Calder, James F Nelson, Jan Vijg   +6 more
doaj   +1 more source

Icelandic mutation accumulation model

, 2017
Icelandic mutation accumulation model (Ibs 0.5-0.99 and Ibs 0.35) - secondary analysis of data from Kong et al. (2012) Rate of de novo mutations and the importance of father’s age to disease risk. Nature 488, 471–475. (doi:10.1038/nature11396), Fig. 4, p.
Woodley of Menie, Michael, Fernandes, Heitor, Michael Woodley of Menie (5015453), Matthew Sarraf (5015462), Sarraf, Matthew, Heitor Fernandes (5015459)   +5 more
core   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The Legacy of Domestication: Accumulation of Deleterious Mutations in the Dog Genome [PDF]

Molecular Biology and Evolution, 2008
Dogs exhibit more phenotypic variation than any other mammal and are affected by a wide variety of genetic diseases. However, the origin and genetic basis of this variation is still poorly understood. We examined the effect of domestication on the dog genome by comparison with its wild ancestor, the gray wolf.
Cruz F, Vilà C, Webster MT
openaire   +4 more sources

Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell–cell interactions [PDF]

, 2014
Variation of mutation rate at a particular site in a particular genotype, in other words mutation rate plasticity (MRP), can be caused by stress or ageing. However, mutation rate control by other factors is less well characterized.
John A. D. Aston, Aston, Elizabeth, Christopher G. Knight, Roman V. Belavkin, Knight, Christopher G., Aston, JA, Aston, John A D, Rash, BM, Knight, C. G. (Christopher G.), Elizabeth Aston, Channon, A, Krašovec, Rok; id_orcid, Knight, CG, An Kadirvel, Aston, John A. D., Forbes, S, Alastair Channon, Channon, Alastair, Knight, Christopher G.; id_orcid, Aston, E, Krašovec, Rok, Belavkin, RV, Forbes, Sarah, Aston, John A.D., Sarah Forbes, Kadirvel, Manikandan, Belavkin, Roman V., Bharat M. Rash, Kadirvel, Manikandan; id_orcid, Rash, Bharat M., Krašovec, R, Kadirvel, M, Channon, A., Belavkin, R., Krašovec, R., Aston, E., Forbes, S., Kadirvel, M., Rash, B., Knight, C., Aston, J.   +40 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Accumulation of deleterious mutations during bacterial range expansions [PDF]

Genetics, 2016
Abstract Recent theory predicts that the fitness of pioneer populations can decline when species expand their range, due to high rates of genetic drift on wave fronts making selection less efficient at purging deleterious variants.
Bosshard, Lars, Dupanloup, Isabelle, Tenaillon, Olivier, Bruggmann, Rémy, Ackermann, Martin, Peischl, Stephan, Excoffier, Laurent   +6 more
openaire   +5 more sources

Use of the q-Gaussian mutation in evolutionary algorithms [PDF]

, 2010
Copyright @ Springer-Verlag 2010.This paper proposes the use of the q-Gaussian mutation with self-adaptation of the shape of the mutation distribution in evolutionary algorithms.
Yang, S, YANG, Shengxiang, Shengxiang Yang, TINOS, Renato, Renato Tinós, Tinós, R   +5 more
core   +1 more source