Results 101 to 110 of about 1,757,426 (287)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis of mutation accumulation experiments : response to

, 2020
Summary A recent paper in this journal by Deng, Li and Li has investigated methods to estimate rates and effects of polygenic mutations using data from mutation accumulation experiments.
Peter D Keightley, Li Deng, Li
core  

Viability of the ancestors and drug-evolved mutation accumulation lines.

, 2023
Viability of the ancestors and drug-evolved mutation accumulation lines.
Jia-Xing Yue (3405950), Ekaterina Mikhalev (8790824), Simon Stenberg (8569728), Dawn Thompson (364182), Jing Li (10611), Gianni Liti (118381), Jonas Warringer (57649)   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The negligible mutagenic effects of norfloxacin on the genome of the fission yeast Schizosaccharomyces pombe ATCC-16979

Microbiology Spectrum
Antibiotic therapy is commonly used in various medical scenarios, and some antibiotics will stay in the blood serum for days. Previous studies have demonstrated that the fluoroquinolone antibiotic norfloxacin exerts mutagenic effects on the whole genomes
Tongtong Lin, Xiaolin Wu, Yelin Lan, Yongchun Huang, Ziguang Deng, Yu Zhang, Michael Lynch, Hongan Long, Jiao Pan   +8 more
doaj   +1 more source

Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors

EBioMedicine, 2020
Background: Clinical responses to EGFR tyrosine kinase inhibitors (TKIs) are restricted to tumors harboring specific activating mutations and even then, not all tyrosine kinase inhibitors provide clinical benefit.
Maurice de Wit, Ya Gao, Darlene Mercieca, Iris de Heer, Bart Valkenburg, Martin E. van Royen, Joachim Aerts, Peter Sillevis Smitt, Pim French   +8 more
doaj   +1 more source

Accumulation patterns of metals in selected plant species - meta-analysis

, 2021
The study investigates the concentration and accumulation of heavy metals in amaranth plant tissues. The results indicate that the accumulation pattern of metals is different.
Yelamanova, Ayash
core  

Fruit-Surface Flavonoid Accumulation in Tomato Is Controlled by a SlMYB12-Regulated Transcriptional Network [PDF]

, 2009
The cuticle covering plants' aerial surfaces is a unique structure that plays a key role in organ development and protection against diverse stress conditions.
Domínguez, Eva, Ilya Venger, Adato, Avital, Zhonghua Wang, Jetter, Reinhard, Mintz-Oron Shira, de Vos, C.H., Heredia, Antonio, Jetter Reinhard, Ric C. H. De Vos, Aharoni Asaph, Ric C H De Vos, Wang, Z., Shira Mintz-Oron, Wang Zhonghua, De Vos Ric C. H., Venger, I., Vos, C.H., de, Levy, D., Aharoni, A., Lukas Schreiber, Heredia Antonio, Adato Avital, Schreiber, Lukas, Rogachev, Ilana, Yativ, M., Venger Ilya, Yativ, Merav, Mandel, T., Schreiber Lukas, Heredia, A., Adato, A., Dorit Levy, Jetter, R., Rogachev, I., Yativ Merav, Wang, Zhonghua, Dominguez, E., Merav Yativ, Mandel, Tali, Mintz-Oron, Shira, Asaph Aharoni, Venger, Ilya, Ilana Rogachev, Aharoni, Asaph, Tali Mandel, Rogachev Ilana, Levy, Dorit, Antonio Heredia, Mintz-Orion, S., Levy Dorit, Schreiber, L., Domínguez Eva, Avital Adato, Eva Domínguez, De Vos, Ric C H, Reinhard Jetter, Mandel Tali   +57 more
core   +2 more sources

Viability of the ancestors and YPD-evolved mutation accumulation lines.

, 2023
Viability of the ancestors and YPD-evolved mutation accumulation lines.
Jia-Xing Yue (3405950), Ekaterina Mikhalev (8790824), Simon Stenberg (8569728), Dawn Thompson (364182), Jing Li (10611), Gianni Liti (118381), Jonas Warringer (57649)   +6 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source