Results 121 to 130 of about 1,757,426 (287)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Semantically Driven Mutation in Genetic Programming [PDF]
, 2008 Using semantic analysis, we present a technique known as semantically driven mutation which can explicitly detect and apply behavioural changes caused by the syntactic changes in programs that result from the mutation operation. Using semantically driven
Beadle, Lawrence +3 more
core +1 more source
Mutation accumulation, selection and time dynamics of GBM tumors.
, 2023 Panels A1-D1 show the primary tumor T1, panels A2-D2 show the recurrent tumor T2. (A) Mutation accumulation as a function of the inverse of allele frequency 1/f (black) and phases from automated segmentation (breakpoints (grey) and segments (blue)).
Günter Raddatz (109578) +4 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The architecture of intra-organism mutation rate variation in plants.
PLoS Biology, 2019 Given the disposability of somatic tissue, selection can favor a higher mutation rate in the early segregating soma than in germline, as seen in some animals.
Long Wang +15 more
doaj +1 more source
Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts. [PDF]
, 2019 The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Mutation testing from probabilistic and stochastic finite state machines [PDF]
, 2009 Specification mutation involves mutating a specification, and for each mutation a test is derived that distinguishes the behaviours of the mutated and original specifications. This approach has been applied with finite state machine based models.
García Merayo, María De Las Mercedes +3 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source