Results 141 to 150 of about 1,757,426 (287)
Mitochondrial DNA mutation in an Italian family with Leber hereditary optic neuropathy
, 1991 Mitochondrial (mt) DNA from a Southern Italian family with Leber hereditary optic neuropathy was analyzed for the presence of the reported mutation at position 11778 of the ND4 subunit gene.
Pontecorvi, Alfredo
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The International Journal of Biological Markers, 2010 The present study evaluated 5 of the 8 main TP53 mutation hot spots in cancer by restriction site mutation analysis and compared the results with p53 protein expression in patients with cancer of the tongue.
Hemangini H. Vora +3 more
doaj +1 more source
Heterogeneity in viral populations increases the rate of deleterious mutation accumulation. [PDF]
Genetics, 2022 Allman B, Koelle K, Weissman D.
europepmc +1 more source
Data from: Mutation accumulation and the formation of range limits
, 2014 The dynamics of range formation are important for understanding and predicting species distributions. Here, we focus on a process that has thus far been overlooked in the context of range formation; the accumulation of mutation load.
Travis, Justin M. J. +2 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Selection in a growing colony biases results of mutation accumulation experiments. [PDF]
Sci Rep, 2022 Mahilkar A, Raj N, Kemkar S, Saini S.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells. [PDF]
iScience, 2022 Manders F, van Dinter J, van Boxtel R.
europepmc +1 more source