Results 171 to 180 of about 1,239,617 (330)

Mutational profiles of spontaneous and radiation-related mammary carcinomas in a rat model of Brca1 haploinsufficiency [PDF]

Yuzuki Nakamura, Kazuhiro Daino, Atsuko Ishikawa, Shizuko Kakinuma, YUKIKO NISHIMURA-YANO, K. Nagata, Masaru Takabatake, Mayumi Nishimura, Tomoji Mashimo, Kazumasa Inoue, Tatsuhiko Imaoka   +10 more
openalex   +3 more sources

TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51^K133A. [PDF]

Cell Rep, 2020
Ko JH, Son MY, Zhou Q, Molnarova L, Song L, Mlcouskova J, Jekabsons A, Montagna C, Krejci L, Hasty P.   +9 more
europepmc   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Developmental speed and chronological time exert opposing effects on the spontaneous mutation rate in Chironomus riparius

Burak Bulut, Markus Pfenninger
  +4 more sources

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Meiotic double strand DNA breaks and spontaneous mutation in Drosophila melanogaster

Nathaniel Sharp, Rob Melde, JoHanna Abraham, Austin Daigle   +3 more
  +5 more sources

Environmental and genetic influence on rate and spectrum of spontaneous mutations in Escherichia coli

, 2023
Gifford DR, Bhattacharyya A, Geim A, Marshall E, Krašovec R, Knight CG.   +5 more
europepmc   +1 more source

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells. [PDF]

Aging Cell, 2020
Novarina D, Janssens GE, Bokern K, Schut T, van Oerle NC, Kazemier HG, Veenhoff LM, Chang M.   +7 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Data and R code for Genetic variation of the effects of spontaneous mutation on size at birth.

Jeff L Dudycha
  +5 more sources